Integrative Radiogenomics Approach for Risk Assessment of Postoperative and Adjuvant Chemotherapy Benefits for Gastric Cancer Patients

被引:8
|
作者
Jin, Yin [1 ]
Xu, Yilun [1 ]
Li, Yanyan [2 ,3 ]
Chen, Renpin [1 ]
Cai, Weiyang [1 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Affiliated Hosp 2, Dept Urol, Wenzhou, Peoples R China
[3] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词
radiogenomics; adjuvant chemotherapy benefit; postoperative gastric cancer; nomogram; survival prediction; GENE-EXPRESSION; CHEMORADIOTHERAPY; SURVIVAL; DICOM;
D O I
10.3389/fonc.2021.755271
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Gastric cancer (GC) is a typical heterogeneous malignant tumor, whose insensitivity to chemotherapy is a common cause of tumor recurrence and metastasis. There is no doubt regarding the effectiveness of adjuvant chemotherapy (ACT) for GC, but the population for whom it is indicated and the selection of specific options remain the focus of present research. The conventional pathological TNM prediction focuses on cancer cells to predict prognosis, while they do not provide sufficient prediction. Enhanced computed tomography (CT) scanning is a validated tool that assesses the involvement of careful identification of the tumor, lymph node involvement, and metastatic spread. Using the radiomics approach, we selected the least absolute shrinkage and selection operator (LASSO) Cox regression model to build a radiomics signature for predicting the overall survival (OS) and disease-free survival (DFS) of patients with complete postoperative gastric cancer and further identifying candidate benefits from ACT. The radiomics trait-associated genes captured clinically relevant molecular pathways and potential chemotherapeutic drug metabolism mechanisms. Our results of precise surrogates using radiogenomics can lead to additional benefit from adjuvant chemotherapy and then survival prediction in postoperative GC patients.
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页数:11
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