Recent trends in analytical methods for the determination of amino acids in biological samples

被引：95

作者：

Song, Yanting ^{[1
]}

Xu, Chang ^{[1
]}

Kuroki, Hiroshi ^{[2
]}

Liao, Yiyi ^{[1
]}

Tsunoda, Makoto ^{[2
]}

机构：

[1] Hainan Univ, Coll Marine Sci, Dept Pharmaceut Sci, Key Lab Trop Biol Resources,Minist Educ, Haikou 570228, Hainan, Peoples R China

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2018年 / 147卷

基金：

中国国家自然科学基金; 日本学术振兴会;

关键词：

Liquid chromatography; Capillary electrophoresis; Fluorescence; Mass spectrometry; Diagnosis; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; PILLAR ARRAY COLUMN; SHEATHLESS ELECTROSPRAY-IONIZATION; CONTACTLESS CONDUCTIVITY DETECTION; HUMAN BLOOD-PLASMA; CAPILLARY-ELECTROPHORESIS; FLUORESCENCE DETECTION; QUANTITATIVE-ANALYSIS; PRECOLUMN DERIVATIZATION;

D O I：

10.1016/j.jpba.2017.08.050

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Amino acids are widely distributed in biological fluids and involved in many biological processes, such as the synthesis of proteins, fatty acids, and ketone bodies. The altered levels of amino acids in biological fluids have been found to be closely related to several diseases, such as type 2 diabetes, kidney disease, liver disease, and cancer. Therefore, the development of analytical methods to measure amino acid concentrations in biological samples can contribute to research on the physiological actions of amino acids and the prediction, diagnosis and understanding of diseases. This review describes the analytical methods reported in 2012-2016 that utilized liquid chromatography and capillary electrophoresis coupled with ultraviolet, fluorescence, mass spectrometry, and electrochemical detection. Additionally, the relationship between amino acid concentrations and several diseases is also summarized. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：35 / 49

页数：15

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