Copper-Catalyzed Domino Synthesis of Quinazolinones via Ullmann-Type Coupling and Aerobic Oxidative C-H Amidation

被引：227
|
作者：
Xu, Wei [1 ]
Jin, Yibao [2 ]
Liu, Hongxia [2 ]
Jiang, Yuyang [2 ]
Fu, Hua [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol Mini, Beijing 100084, Peoples R China
[2] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 06期
基金：
中国国家自然科学基金;
关键词：
ARYL HALIDES; EFFICIENT SYNTHESIS; N-ARYLATION; DERIVATIVES; LIGAND; AMINES; ALKALOIDS; CHEMISTRY; NITROGEN; AMIDES;
D O I：
10.1021/ol1030266
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient copper-catalyzed approach to quinazolinone derivatives has been developed, and the protocol uses cheap and readily available substituted 2-halobenzamides and (aryl)methanamines as the starting materials as well as economical and environmentally friendly air as the oxidant. This can be the first example of constructing N-heterocycles via sequential Ullmann-type coupling under air and aerobic oxidative C-H amidation.
引用
收藏
页码：1274 / 1277
页数：4
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