Copper-Catalyzed Domino Synthesis of Quinazolinones via Ullmann-Type Coupling and Aerobic Oxidative C-H Amidation

被引：227

作者：

Xu, Wei ^{[1
]}

Jin, Yibao ^{[2
]}

Liu, Hongxia ^{[2
]}

Jiang, Yuyang ^{[2
]}

Fu, Hua ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol Mini, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ARYL HALIDES; EFFICIENT SYNTHESIS; N-ARYLATION; DERIVATIVES; LIGAND; AMINES; ALKALOIDS; CHEMISTRY; NITROGEN; AMIDES;

D O I：

10.1021/ol1030266

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed approach to quinazolinone derivatives has been developed, and the protocol uses cheap and readily available substituted 2-halobenzamides and (aryl)methanamines as the starting materials as well as economical and environmentally friendly air as the oxidant. This can be the first example of constructing N-heterocycles via sequential Ullmann-type coupling under air and aerobic oxidative C-H amidation.

引用

页码：1274 / 1277

页数：4

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