IL-10-producing regulatory B cells (B10 cells), IL-17+T cells and autoantibodies in systemic sclerosis

被引：21
|
作者：
Mavropoulos, Athanasios [1 ]
Liaskos, Christos [1 ]
Simopoulou, Theodora [1 ]
Bogdanos, Dimitrios P. [1 ]
Sakkas, Lazaros I. [1 ]
机构：
[1] Univ Thessaly, Sch Hlth Sci, Dept Rheumatol & Clin Immunol, Fac Med, Larisa 40500, Greece
来源：
CLINICAL IMMUNOLOGY | 2017年 / 184卷
关键词：
Autoimmunity; Autoantibody; B regulatory cells; Scleroderma; T cells; MURINE LUPUS; FIBROSIS; DISEASE; MICE; AUTOIMMUNITY; MECHANISMS; VASCULITIS;
D O I：
10.1016/j.clim.2017.04.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFN gamma + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17 + and IFN gamma + T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17 + CD3 + cells and IFN gamma + CD3 + cells. IL-17 + CD3 + cells did not correlate with autoAb levels, but IFN-gamma + CD3 + cells were inversely correlated with anti-Topo I levels. In conclusion, in SSc, B10 cells did not correlate with SSc-specific autoAbs and exhibited an inverse correlation with IL-17+ T cells and IFN gamma + T cells. (C) 2017 Elsevier Inc. All rights reserved.
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页码：26 / 32
页数：7
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