IL-10-producing regulatory B cells (B10 cells), IL-17+T cells and autoantibodies in systemic sclerosis

被引：21
|
作者：
Mavropoulos, Athanasios [1 ]
Liaskos, Christos [1 ]
Simopoulou, Theodora [1 ]
Bogdanos, Dimitrios P. [1 ]
Sakkas, Lazaros I. [1 ]
机构：
[1] Univ Thessaly, Sch Hlth Sci, Dept Rheumatol & Clin Immunol, Fac Med, Larisa 40500, Greece
来源：
CLINICAL IMMUNOLOGY | 2017年 / 184卷
关键词：
Autoimmunity; Autoantibody; B regulatory cells; Scleroderma; T cells; MURINE LUPUS; FIBROSIS; DISEASE; MICE; AUTOIMMUNITY; MECHANISMS; VASCULITIS;
D O I：
10.1016/j.clim.2017.04.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFN gamma + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17 + and IFN gamma + T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17 + CD3 + cells and IFN gamma + CD3 + cells. IL-17 + CD3 + cells did not correlate with autoAb levels, but IFN-gamma + CD3 + cells were inversely correlated with anti-Topo I levels. In conclusion, in SSc, B10 cells did not correlate with SSc-specific autoAbs and exhibited an inverse correlation with IL-17+ T cells and IFN gamma + T cells. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：26 / 32
页数：7
相关论文
共 50 条
  • [1] IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
    Kalampokis, Ioannis
    Yoshizaki, Ayumi
    Tedder, Thomas F.
    ARTHRITIS RESEARCH & THERAPY, 2013, 15
  • [2] IL-10-producing regulatory B cells (B10 cells) in autoimmune disease
    Ioannis Kalampokis
    Ayumi Yoshizaki
    Thomas F Tedder
    Arthritis Research & Therapy, 15
  • [3] IL-10-PRODUCING REGULATORY B CELLS ARE DECREASED IN SYSTEMIC SCLEROSIS
    Mavropoulos, A.
    Simopoulou, T.
    Varna, A.
    Liaskos, C.
    Katsiari, C.
    Bogdanos, D.
    Sakkas, L.
    ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 423 - 423
  • [4] IL-10-Producing Regulatory B Cells (B10 cells) Inhibit Intestinal Injury In Mice
    Yanaba, Koichi
    Sato, Shinichi
    ARTHRITIS AND RHEUMATISM, 2011, 63 (10): : S689 - S690
  • [5] The IL-10-producing regulatory B cells (B10 cells) and regulatory T cell subsets in neuromyelitis optica spectrum disorder
    Eun Bin Cho
    Hye-Jin Cho
    Jin Myoung Seok
    Ju-Hong Min
    Eun-Suk Kang
    Byoung Joon Kim
    Neurological Sciences, 2018, 39 : 543 - 549
  • [6] The IL-10-producing regulatory B cells (B10 cells) and regulatory T cell subsets in neuromyelitis optica spectrum disorder
    Yuan Sun
    Ying Huang
    Wei-Wei Chen
    Juan Jia
    Tao Wei
    Neurological Sciences, 2018, 39 : 1307 - 1308
  • [7] The IL-10-producing regulatory B cells (B10 cells) and regulatory T cell subsets in neuromyelitis optica spectrum disorder
    Cho, Eun Bin
    Cho, Hye-Jin
    Seok, Jin Myoung
    Min, Ju-Hong
    Kang, Eun-Suk
    Kim, Byoung Joon
    NEUROLOGICAL SCIENCES, 2018, 39 (03) : 543 - 549
  • [8] The IL-10-producing regulatory B cells (B10 cells) and regulatory T cell subsets in neuromyelitis optica spectrum disorder
    Sun, Yuan
    Huang, Ying
    Chen, Wei-Wei
    Jia, Juan
    Wei, Tao
    NEUROLOGICAL SCIENCES, 2018, 39 (07) : 1307 - 1308
  • [9] IL-10-Producing Regulatory B10 Cells Inhibit Intestinal Injury in a Mouse Model
    Yanaba, Koichi
    Yoshizaki, Ayumi
    Asano, Yoshihide
    Kadono, Takafumi
    Tedder, Thomas F.
    Sato, Shinichi
    AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (02): : 735 - 743
  • [10] Regulatory role of IL-10-producing B cells in psoriasis
    Li Wei
    Wan Ming
    Ren Jing
    Gao Ji-xin
    Liu Yu-feng
    JOURNAL OF DERMATOLOGY, 2012, 39 : 240 - 240
12345