Red pigment produced by Zooshikella ganghwensis inhibited the growth of human cancer cell lines and MMP-1 gene expression

被引：9

作者：

Oh, Eun-Ji ^{[1
]}

Kwon, Jung-Hwa ^{[1
]}

Kim, Su-Yeon ^{[1
]}

In, Seo-Ji ^{[1
]}

Lee, Dong-Geol ^{[2
]}

Cha, Mi-Yeon ^{[2
]}

Kang, Hee-Cheol ^{[2
]}

Hwang-Bo, Jeon ^{[1
]}

Lee, Youn-Hyung ^{[3
]}

Chung, In-Sik ^{[1
]}

Baek, Nam-In ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Oriental Med & Biotechnol, Grad Sch Biotechnol, Yongin 446701, South Korea

[2] GFC Co Ltd, Ctr Res & Dev, Suwon 443813, South Korea

[3] Kyung Hee Univ, Dept Hort Biotechnol, Yongin 446701, South Korea

来源：

APPLIED BIOLOGICAL CHEMISTRY | 2016年 / 59卷 / 04期

关键词：

Anti-aging activity; Cytotoxic activity; Human cancer cell line; Matrix metalloproteinase-1; Prodigiosin; Zooshikella ganghwensis;

D O I：

10.1007/s13765-016-0196-1

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A red pigment produced by Zooshikella ganghwensis, was purified by solvent extraction and fractionation. The pigment was identified to be prodigiosin on the basis of spectroscopic data such as H-1-NMR, C-13-NMR, DEPT, 2D-NMR, IR, and FAB-MS. Prodigiosin inhibited matrix metalloproteinase-1 gene expression and the growth of human cancer cell lines, SK-BR-3, HCT-116, SK-OV-3, HeLa, HepG2, and SK-MEL-5.

引用

页码：567 / 571

页数：5

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