Optimal dose of propofol for intubation after sevoflurane inhalation without neuromuscular blocking agent in children

被引:8
作者
Jo, Y. Y. [1 ]
Jun, N. H. [1 ]
Kim, E. J. [1 ]
Choi, E. K. [1 ]
Kil, H. K. [1 ]
机构
[1] Yonsei Univ, Coll Med, Dept Anaesthesiol & Pain Med, Seoul 120752, South Korea
关键词
TRACHEAL INTUBATION; PEDIATRIC-PATIENTS; EPILEPTIFORM EEG; INDUCTION; ANESTHESIA; HALOTHANE;
D O I
10.1111/j.1399-6576.2010.02383.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background This study was designed to determine the optimal dose of propofol for excellent intubating conditions in children without neuromuscular blockade at various alveolar concentrations of sevoflurane. Methods Sixty-three children, aged 0.5-5 years, were randomized to three groups of end-tidal sevoflurane concentration (ETsevo) 3%, 3.5%, and 4%. Inhalation anesthesia was started with sevoflurane 7% in 100% oxygen. When the patients became unconscious, inspired concentration was adjusted to obtain the target ETsevo for each group. When ETsevo reached the target concentration, a predetermined dose of propofol was given and tracheal intubation was performed. The proper dose of propofol was determined using the 'up-and-down' method. Results The median dose (95% confidence intervals) of propofol for excellent tracheal intubating conditions in 50% of children were 1.25 mg/kg (0.84-1.75) at ETsevo of 3%, 0.76 mg/kg (0.35-1.21) at 3.5%, and 0.47 mg/kg (0.26-1.09) at 4%. The frequency of adverse effects was not different between groups during induction and recovery. Conclusion Propofol 1.5-2 mg/kg provides excellent intubating conditions at 3-4% ETsevo in children without using any neuromuscular blocking agent.
引用
收藏
页码:332 / 336
页数:5
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