Evaluating the effect of immune cells on the outcome of patients with mesothelioma

被引：49

作者：

Chee, Serena J. ^{[1
,2
]}

Lopez, Maria ^{[1
,3
]}

Mellows, Toby ^{[3
,4
]}

Gankande, Sharmali ^{[3
]}

Moutasim, Karwan A. ^{[1
,3
]}

Harris, Scott ^{[5
]}

Clarke, James ^{[1
]}

Vijayanand, Pandurangan ^{[4
]}

Thomas, Gareth J. ^{[1
,6
]}

Ottensmeier, Christian H. ^{[1
,2
,6
]}

机构：

[1] Univ Southampton, Canc Sci Unit, Fac Med, Tremona Rd, Southampton SO16 6YD, Hants, England

[2] Southampton Gen Hosp, NIHR Southampton Biomed Res Ctr, Tremona Rd, Southampton SO16 6YD, Hants, England

[3] Univ Hosp Southampton NHS Fdn Trust, Dept Cellular Pathol, Tremona Rd, Southampton SO16 6YD, Hants, England

[4] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton Natl Inst Hlth Res Resp,Biomed Res Un, Southampton SO16 6YD, Hants, England

[5] Univ Southampton, Publ Hlth Sci & Med Stat, Tremona Rd, Southampton SO16 6YD, Hants, England

[6] NIHR CRUK Expt Canc Med Ctr Southampton, Tremona Rd, Southampton SO16 7YD, Hants, England

来源：

BRITISH JOURNAL OF CANCER | 2017年 / 117卷 / 09期

关键词：

mesothelioma; cancer immunology; tissue microarray; MALIGNANT PLEURAL MESOTHELIOMA; TUMOR-INFILTRATING LYMPHOCYTES; PROGNOSTIC VALUE; T-CELLS; OPEN-LABEL; CANCER; CHEMOTHERAPY; EXPRESSION; MUTATIONS; LANDSCAPE;

D O I：

10.1038/bjc.2017.269

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: We systematically assessed the prognostic and predictive value of infiltrating adaptive and innate immune cells in a large cohort of patients with advanced mesothelioma. Methods: A tissue microarray from 302 samples was constructed. Markers of adaptive immune response in T-cells (CD8(+), FOXP3(+), CD4(+), CD45RO(+), CD3(+)) and B-cells (CD20(+)), and of innate immune response; neutrophils (NP57(+)), natural killer cells (CD56(+)) and macrophages (CD68(+)) were evaluated. Results: We found that in the epithelioid tumours, high CD4(+) and CD20(+) counts, and low FOXP3(+), CD68(+) and NP57(+) counts linked to better outcome. In the non-epithelioid group low CD8(+) and low FOXP3(+)counts were beneficial. On multivariate analysis low FOXP3(+) remained independently associated with survival in both groups. In the epithelioid group additionally high CD4(+), high CD20(+), and low NP57(+) counts were prognostic. Conclusions: Our data demonstrate for the first time, in predominately advanced disease, the association of key markers of adaptive and innate immunity with survival and the differential effect of histology. A better understanding of the immunological drivers of the different subtypes of mesothelioma will assist prognostication and disease-specific clinical decision-making.

引用

页码：1341 / 1348

页数：8

共 41 条

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