Preparation, characterization and application of superparamagnetic iron oxide encapsulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride

被引：17
|
作者：
Shen, Chia-Rui [1 ,2 ]
Juang, Jyuhn-Huarng [3 ]
Tsai, Zei-Tsan [2 ]
Wu, Shu-Ting [1 ]
Tsai, Fu-Yuan [4 ]
Wang, Jiun-Jie [2 ,5 ]
Liu, Chao-Lin [6 ,7 ]
Yen, Tzu-Chen [2 ,5 ]
机构：
[1] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Tao Yuan, Taiwan
[2] Chang Gung Mem Hosp, Mol Imaging Ctr, Tao Yuan, Taiwan
[3] Chang Gung Univ, Div Endocrinol & Metab, Dept Internal Med, Tao Yuan, Taiwan
[4] Chang Gung Univ, Gen Educ Ctr, Tao Yuan, Taiwan
[5] Chang Gung Univ, Dept Med Imaging & Radiol Sci, Tao Yuan, Taiwan
[6] Ming Chi Univ Technol, Grad Sch Biochem Engn, Taipei, Taiwan
[7] Ming Chi Univ Technol, Dept Chem Engn, Taipei, Taiwan
来源：
CARBOHYDRATE POLYMERS | 2011年 / 84卷 / 02期
关键词：
Cell tracking; Chitosan; Ferrofluid; N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC); Islet transplantation; Magnetic resonance image; Superparamagnetic iron oxide nanocrystals (SPION); TRANSPLANTED PANCREATIC-ISLETS; WATER-SOLUBLE CHITOSAN; CONTRAST AGENTS; IN-VITRO; NANOPARTICLES; CELLS; MRI; PARTICLES; DELIVERY; DEXTRAN;
D O I：
10.1016/j.carbpol.2010.07.067
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Superparamagnetic iron oxide nanocrystals (SPION) and their colloidal solutions of magnetic nanoparticles (ferrofluid) appear to contribute to the magnetite imaging applications. Here we present an aqueous ferrofluid in physiological pH and its cell tracking potential. In situ coating method was adapted to synthesize N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC)-coated SPION. Characterization results reveal their features as follows: (1) z-average diameter of 274.1 +/- 1.934 nm; (2) polydispersity index (PDI) of 0.135 +/- 0.029; (3) zeta potential of 11.4 +/- 0.410 mV; (4) iron concentration of 5.4 mg Fe/ml; (5) stable in both water and normal saline; (6) uptake by a variety of cell lines and (7) little cytotoxicity. Finally, islet grafting experiments demonstrated the potential usefulness of this product as a MRI contrast agent for cell tracking. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：781 / 787
页数：7
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