Preparation, characterization and application of superparamagnetic iron oxide encapsulated with N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride

被引：17
|
作者：
Shen, Chia-Rui [1 ,2 ]
Juang, Jyuhn-Huarng [3 ]
Tsai, Zei-Tsan [2 ]
Wu, Shu-Ting [1 ]
Tsai, Fu-Yuan [4 ]
Wang, Jiun-Jie [2 ,5 ]
Liu, Chao-Lin [6 ,7 ]
Yen, Tzu-Chen [2 ,5 ]
机构：
[1] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Tao Yuan, Taiwan
[2] Chang Gung Mem Hosp, Mol Imaging Ctr, Tao Yuan, Taiwan
[3] Chang Gung Univ, Div Endocrinol & Metab, Dept Internal Med, Tao Yuan, Taiwan
[4] Chang Gung Univ, Gen Educ Ctr, Tao Yuan, Taiwan
[5] Chang Gung Univ, Dept Med Imaging & Radiol Sci, Tao Yuan, Taiwan
[6] Ming Chi Univ Technol, Grad Sch Biochem Engn, Taipei, Taiwan
[7] Ming Chi Univ Technol, Dept Chem Engn, Taipei, Taiwan
来源：
CARBOHYDRATE POLYMERS | 2011年 / 84卷 / 02期
关键词：
Cell tracking; Chitosan; Ferrofluid; N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC); Islet transplantation; Magnetic resonance image; Superparamagnetic iron oxide nanocrystals (SPION); TRANSPLANTED PANCREATIC-ISLETS; WATER-SOLUBLE CHITOSAN; CONTRAST AGENTS; IN-VITRO; NANOPARTICLES; CELLS; MRI; PARTICLES; DELIVERY; DEXTRAN;
D O I：
10.1016/j.carbpol.2010.07.067
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Superparamagnetic iron oxide nanocrystals (SPION) and their colloidal solutions of magnetic nanoparticles (ferrofluid) appear to contribute to the magnetite imaging applications. Here we present an aqueous ferrofluid in physiological pH and its cell tracking potential. In situ coating method was adapted to synthesize N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC)-coated SPION. Characterization results reveal their features as follows: (1) z-average diameter of 274.1 +/- 1.934 nm; (2) polydispersity index (PDI) of 0.135 +/- 0.029; (3) zeta potential of 11.4 +/- 0.410 mV; (4) iron concentration of 5.4 mg Fe/ml; (5) stable in both water and normal saline; (6) uptake by a variety of cell lines and (7) little cytotoxicity. Finally, islet grafting experiments demonstrated the potential usefulness of this product as a MRI contrast agent for cell tracking. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：781 / 787
页数：7
相关论文
共 48 条
  • [1] Investigation of the properties of N-[(2-hydroxy-3-trimethylammonium) propyl] chloride chitosan derivatives
    Shagdarova, Balzhima
    Lunkov, Alexey
    Il'ina, Alla
    Varlamov, Valery
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 124 : 994 - 1001
  • [2] Neutralization of anticoagulant activity of heparin by N-[(2-hydroxy-3-trimethylammonium) propyl] chloride derivatives of chitosan
    Shagdarova, B. Ts.
    Drozd, N. N.
    Il'ina, A. V.
    Logvinova, Yu. S.
    Varlamov, V. P.
    APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2016, 52 (04) : 445 - 451
  • [3] NKG2D-IL-15 fusion protein encapsulated in N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride retards melanoma growth in mice
    Chen, Rong
    Ding, Yimei
    Xi, Juqun
    Lu, Guotao
    Xiao, Weiming
    Ding, Yanbing
    Qian, Li
    Lin, Zhijie
    Gong, Weijuan
    TRANSLATIONAL CANCER RESEARCH, 2019, 8 (06) : 2230 - 2241
  • [4] Water-soluble N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride as a nucleic acids vector for cell transfection
    Faizuloev, Evgeny
    Marova, Anna
    Nikonova, Alexandra
    Volkova, Irina
    Gorshkova, Marina
    Izumrudov, Vladimir
    CARBOHYDRATE POLYMERS, 2012, 89 (04) : 1088 - 1094
  • [5] Interleukin-12 Plasmid DNA Delivery by N-[(2-Hydroxy-3-trimethylammonium)propyl]chitosan-Based Nanoparticles
    Dehshahri, Ali
    Khalvati, Bahman
    Taheri, Zahra
    Safari, Farshad
    Mohammadinejad, Reza
    Heydari, Abolfazl
    POLYMERS, 2022, 14 (11)
  • [6] Preparation and catalytic performance of N-[(2-Hydroxy-3-trimethylammonium) propyl] chitosan chloride/Na2SiO3 polymer based catalyst for biodiesel production
    Liang, Mengzhu
    He, Benqiao
    Shao, Yixuan
    Li, Jianxin
    Cheng, Yu
    RENEWABLE ENERGY, 2016, 88 : 51 - 57
  • [7] Synthesis and characterization of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride for potential application in gene delivery
    Xiao, Bo
    Wan, Ying
    Wang, Xiaoyu
    Zha, Qichen
    Liu, Haoming
    Qiu, Zhiye
    Zhang, Shengmin
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2012, 91 : 168 - 174
  • [8] Cholic acid modified N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride for superoxide dismutase delivery
    Cheng, Ye
    Cai, Huanxin
    Yin, Baoru
    Yao, Ping
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 454 (01) : 425 - 434
  • [9] Synthesis and characteristics of chitin and chitosan with the (2-hydroxy-3-trimethylammonium)propyl functionality, and evaluation of their antioxidant activity in vitro
    Zhang, Xiao
    Geng, Xiaodong
    Jiang, Hengjun
    Li, Jianrong
    Huang, Jianying
    CARBOHYDRATE POLYMERS, 2012, 89 (02) : 486 - 491
  • [10] Synthesis and characterization of cinnamic acid conjugated N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride derivatives: A hybrid flocculant with antibacterial activity
    Wang, Min
    Yue, Lin
    Niazi, Sobia
    Khan, Imran Mahmood
    Zhang, Yin
    Wang, Zhouping
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 206 : 886 - 895
12345