A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids

被引：38

作者：

Nadai, Matteo ^{[1
]}

Doria, Filippo ^{[2
]}

Scalabrin, Matteo ^{[1
]}

Pirota, Valentina ^{[2
]}

Grande, Vincenzo ^{[2
]}

Bergamaschi, Greta ^{[2
]}

Amendola, Valeria ^{[2
]}

Winnerdy, Fernaldo Richtia ^{[3
]}

Anh Tuan Phan ^{[3
]}

Richter, Sara N. ^{[1
]}

Freccero, Mauro ^{[2
]}

机构：

[1] Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy

[2] Univ Pavia, Dept Chem, V le Taramelli 10, I-27100 Pavia, Italy

[3] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 44期

基金：

欧洲研究理事会;

关键词：

NAPHTHALENE DIIMIDES; COPPER-COMPLEXES; DNA CLEAVAGE; PROMOTER; RNA; CANCER; MECHANISM; SCISSION; LIGANDS; BINDING;

D O I：

10.1021/jacs.8b05337

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and mass spectrometry experiments highlight a unique and unexpected selectivity in cleaving G-quadruplex sequences. This selectivity relies both on the binding affinity and structural features of the targeted G-quadruplexes.

引用

页码：14528 / 14532

页数：5

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