Synthesis and structure of O,O-diethyl N-[(trans-4-aryl-5,5-dimethyl-2-oxido-2λ5-1,3,2-dioxaphosphorinan-2-yl)methyl]phosphoramidothioates

被引：8

作者：

Miao, Zhiwei ^{[1
]}

Zhang, Jianfeng ^{[1
]}

Cui, Zhanwei ^{[1
]}

Wang, Bin ^{[1
]}

Chen, Ruyu ^{[1
]}

机构：

[1] Nankai Univ, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2007年 / 90卷 / 10期

关键词：

D O I：

10.1002/hlca.200790201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study on the synthesis of the novel N-(cyclic phosphonate)-substituted phosphoramidothioates, i.e.. O,O-diethyl N-[(trans-4-aryl-5,5-dimethyl-2-oxido-2 lambda(5)-1,3,2-dioxaphosphorinan-2-yl)methyl]phosphoramidothioates 4a-1. from O,O-diethyl phosphoramidothioate (1), a benzaldehyde or ketone 2, and a 1.3.2-dioxaphosphorinane 2-oxide 3 was carried out (Scheme 1 and Table 1). Some of their stereoisomers were isolated, and their structure was established. The presence of acetyl chloride was essential for this reaction and accelerated the process of intramolecular dehydration of intermediate 5 forming the corresponding Schiff base 7 (Scheme 2).

引用

收藏

页码：1932 / 1939

页数：8

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