Concentrations of Glucose and Insulin in Normal-Weight, Apparently Healthy Women - Where Does Insulin Resistance Start?

被引:2
作者
Moltz, L. [1 ]
Holl, R. W. [2 ]
机构
[1] Inst Pravent Med, D-10623 Berlin, Germany
[2] Med Fak Ulm, Abt Epidemiol, Ulm, Germany
关键词
insulin resistance; oral glucose tolerance test (o-GTT); HOMA-IR; Belfiore-IS; HOMEOSTASIS MODEL ASSESSMENT; FOR-GESTATIONAL-AGE; BIRTH-WEIGHT; BODY-COMPOSITION; OVERWEIGHT; CHILDREN; ADIPONECTIN; SENSITIVITY; CLASSIFICATION; INFLAMMATION;
D O I
10.1055/s-0030-1262712
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Insulin resistance (IR), like typeII diabetes, is being diagnosed in younger age groups. This raises the question as to which glucose and insulin values are appropriate in normal-weight, apparently healthy adults. 289female subjects aged 17-56years consented to an oral glucose tolerance test (OGTT). By definition - 90(th) percentile - the threshold values were 97mg/dl for fasting glucose, 14.8 mu U/ml for fasting insulin and 4.1 for the HOMA-insulin resistance-index (HOMA-IR). When only fasting insulin and HOMA-IR were taken into consideration, 14.9% of subjects had IR, increasing to 22.5% when insulin sensitivity based on the OGTT (Belfiore-Index) were additionally considered. These results underline the need for an OGTT with measurements of both glucose and insulin, for early detection of IR. As IR even in normal-weight, apparently healthy women can lead to serious micro-and macroangiopathy, early prevention is necessary to avoid secondary complications. So for one should discriminate between primary IR (without any pathology) and secondary IR (with additional pathology).
引用
收藏
页码:372 / 378
页数:7
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