MOC-31/Ep-CAM immunoreactivity in Merkel cells and Merkel cell carcinomas

被引：18
作者：
García-Caballero, T
Pintos, E
Gallego, R
Parrado, C
Blanco, M
Bjornhagen, V
Forteza, J
Beiras, A
机构：
[1] Univ Clin Hosp Santiago de Compostela, Fac Med, Dept Morphol Sci, Santiago De Compostela 15782, Spain
[2] Univ Clin Hosp Santiago de Compostela, Fac Med, Dept Pathol, Santiago De Compostela 15782, Spain
[3] Univ Malaga, Dept Histol & Pathol, E-29071 Malaga, Spain
[4] Karolinska Hosp, Dept Reconstruct Plast Surg, S-10401 Stockholm, Sweden
来源：
HISTOPATHOLOGY | 2003年 / 43卷 / 05期
关键词：
MOC-31; Ep-CAM; EGP-2; Merkel cell carcinoma; immunohistochemistry;
D O I：
10.1046/j.1365-2559.2003.01727.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Aims: To evaluate the monoclonal antibody MOC-31 in Merkel cell carcinomas and normal Merkel cells. Merkel cell carcinoma is a rare and aggressive tumour that occurs mainly in elderly individuals. The histological diagnosis of Merkel cell carcinoma can be difficult because it looks similar to other small blue cell tumours, particularly skin metastases of small-cell lung carcinomas. This antibody recognizes the epithelial cell adhesion molecule (Ep-CAM), that has been assigned to the small cell lung cancer cluster 2 of antibodies. To the best of our knowledge, immunostaining for MOC-31/Ep-CAM has not been previously described in Merkel cells or Merkel cell carcinomas. Methods and results: Thirty-one cases of Merkel cell carcinoma and three samples of normal human fingertip were selected to analyse the expression of MOC-31/Ep-CAM by immunohistochemistry. A high number of Merkel cell carcinomas (21/31, 67.7%) showed intense and readily interpretable positivity. Immunostaining was diffuse or focal and always localized to the plasma membrane. Normal Merkel cells of human fingertip also showed plasma membrane immunoreactivity for MOC-31/Ep-CAM. Conclusion: The demonstration of positivity for MOC-31/Ep-CAM in Merkel cell carcinomas precludes the use of this immunohistochemical marker to distinguish between tumours and skin metastases of small-cell lung carcinoma.
引用
收藏
页码：480 / 484
页数：5
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