Recent advances of dicyano-based materials in biology and medicine

被引：63

作者：

Zhang, Weijie ^{[1
]}

Huo, Fangjun ^{[2
]}

Yin, Caixia ^{[1
]}

机构：

[1] Shanxi Univ, Key Lab Chem Biol & Mol Engn, Key Lab Mat Energy Convers & Storage Shanxi Prov, Minist Educ,Inst Mol Sci, Taiyuan 030006, Peoples R China

[2] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 43期

基金：

中国国家自然科学基金;

关键词：

INFRARED FLUORESCENT-PROBE; LARGE STOKES SHIFT; TURN-ON PROBE; AGGREGATION-INDUCED EMISSION; HIGHLY SELECTIVE DETECTION; IN-VIVO; HYDROGEN-SULFIDE; DRUG-RELEASE; FAR-RED; CYSTEINE;

D O I：

10.1039/c8tb02205d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Fluorescence imaging is advancing quickly through the discovery of new fluorescent molecules and the invention of various strategies that can optimize and detect the fluorescence of various fluorophores. Dicyano-based fluorescent materials, including DCM (dicyanomethylene-4Hpyran) and DCO (dicyanoisophorone), have attracted great attention in recent years due to their excellent photophysical properties, outstanding biocompatibility, and low toxicity to living systems. In this review, we describe the principal strategies to create dicyano-based chemosensors through synthetic methods and the current photophysical understanding of these compounds. Then, we discuss efforts to target small-molecule compounds for imaging cellular events and studying biological processes. Additionally, dicyan-based materials applied to diagnostic tools, drug delivery and potential therapeutics have been described in detail. Finally, we conclude by discussing the opportunities and challenges of this class of materials, which may act as precision tools in the areas of biology and medicine.

引用

页码：6919 / 6929

页数：11

共 103 条

[1] Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents [J].