Pharmaceutical nanocrystals: A promising approach for improved topical drug delivery

被引：64

作者：

Parmar, Prashantkumar K. ^{[1
]}

Wadhawan, Jhanvi ^{[2
]}

Bansal, Arvind K. ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut, Solid State Pharmaceut Lab, Sect 67,SAS Nagar, Mohali 160062, Punjab, India

[2] Dr Reddys Labs Ltd, IPDO, Survey 54, Medchal Malkajgiri 500090, Telangana, India

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 10期

关键词：

Nanocrystals; Nanosuspensions; Nanocrystal-based formulations; Topical drug delivery; MEDIUM SOLUBLE ACTIVES; IN-VIVO FATE; DICLOFENAC ACID; FORMULATION DEVELOPMENT; DERMAL DELIVERY; PARTICLE-SIZE; HUMAN SKIN; NANOSUSPENSIONS; PENETRATION; TECHNOLOGY;

D O I：

10.1016/j.drudis.2021.07.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The barrier function of skin and the non-optimal physicochemical properties of drugs present challenges to the skin penetration of many drugs, thus motivating the development of novel drug delivery systems. Recently, nanocrystal-based formulations have been investigated for topical drug delivery and have demonstrated improved skin penetration. This review highlights barriers in skin penetration, current techniques to improve topical delivery and application of nanocrystals in conquering obstacles for topical delivery. Nanocrystals can improve delivery through the skin by mechanisms including the creation of a higher concentration gradient across skin resulting in increased passive diffusion, hair follicle targeting, formation of diffusional corona, and adhesion to skin. The recent research would be of interest for formulation scientists seeking to develop products involving molecules that are 'difficult-to-deliver' topically.

引用

页码：2329 / 2349

页数：21

共 146 条

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