Location, location, location CD103 demarcates intraepithelial, prognostically favorable CD8+ tumor-infiltrating lymphocytes in ovarian cancer

被引：41
作者：
Webb, John R. [1 ,2 ]
Milne, Katy [1 ]
Nelson, Brad H. [1 ,2 ,3 ]
机构：
[1] British Columbia Canc Agcy, Trev & Joyce Deeley Res Ctr, Victoria, BC, Canada
[2] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC, Canada
[3] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 02期
关键词：
cancer; CD103; epithelium; tumor-infiltrating lymphocytes; T-CELLS; DESTRUCTION; PROGNOSIS;
D O I：
10.4161/onci.27668
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin a E, ITGAE) abundantly infiltrate HGSCs, strongly correlating with increased disease-specific survival.
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