Substituted Pyrazoles and Their Heteroannulated Analogs-Recent Syntheses and Biological Activities

被引：20
作者：
Ramadan, Mohamed [1 ]
Aly, Ashraf A. [2 ]
El-Haleem, Lamiaa E. Abd [2 ]
Alshammari, Mohammed B. [3 ]
Braese, Stefan [4 ,5 ]
机构：
[1] Al Azhar Univ, Assiut Branch, Dept Organ Chem, Fac Pharm, Assiut 71524, Egypt
[2] Minia Univ, Dept Chem, Fac Sci, El Minia 61519, Egypt
[3] Prince Sattam Bin Abdulaziz Univ, Dept Chem, Coll Sci & Humanities, POB 83, Al Kharij 11942, Saudi Arabia
[4] Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany
[5] Karlsruhe Inst Technol, Inst Biol & Chem Syst IBCS FMS, D-76344 Eggenstein Leopoldshafen, Germany
来源：
MOLECULES | 2021年 / 26卷 / 16期
关键词：
pyrazole; heteroannulated; synthesis; reactions; biological activity; ONE-POT SYNTHESIS; SELECTIVE COX-2 INHIBITORS; ANTIMICROBIAL ACTIVITY; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; MONOAMINE-OXIDASE; IONIC LIQUID; ANTIMYCOBACTERIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; HETEROCYCLIC SYNTHESIS;
D O I：
10.3390/molecules26164995
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives. Therefore, we focused our attention on recent topics, up until 2020, for the synthesis of pyrazoles, their heteroannulated derivatives, and their applications as biologically active moieties. Moreover, we focused on traditional procedures used in the synthesis of pyrazoles.
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共 202 条
  • [1] Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities
    Abdel-Aziz, Mohamed
    Abuo-Rahma, Gamal El-Din A.
    Hassan, Alaa A.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (09) : 3480 - 3487
  • [2] Reactions with Hydrazonoyl Halides 62: Synthesis and Antimicrobial Evaluation of Some New Imidazo [1,2-a]pyrimidine, Imidazo [1,2-a]pyridine, Imdazo [1,2-b]pyrazole, and Quinoxaline Derivatives
    Abdelhamid, Abdou O.
    Abdelall, Eman K. A.
    Zaki, Yasser H.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (02) : 477 - 482
  • [3] New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents
    Abdellatif, Khaled R. A.
    El-Saadi, Mohammed T.
    Elzayat, Shaimaa G.
    Amin, Noha H.
    [J]. FUTURE MEDICINAL CHEMISTRY, 2019, 11 (15) : 1871 - 1887
  • [4] Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors
    Abdellatif, Khaled R. A.
    Fadaly, Wael A. A.
    Kamel, Gehan M.
    Elshaier, Yaseen A. M. M.
    El-Magd, Mohammed A.
    [J]. BIOORGANIC CHEMISTRY, 2019, 82 : 86 - 99
  • [5] Synthesis, biological evaluation and molecular modeling study of 5-trifluoromethy1-Δ2-pyrazoline and isomeric 5/3-trifluoromethylpyrazole derivatives as anti-inflammatory agents
    Aggarwal, Ranjana
    Bansal, Anshul
    Rozas, Isabel
    Kelly, Brendan
    Kaushik, Pawan
    Kaushik, Dhirender
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 70 : 350 - 357
  • [6] One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling
    Ahmed, MSM
    Kobayashi, K
    Mori, A
    [J]. ORGANIC LETTERS, 2005, 7 (20) : 4487 - 4489
  • [7] Akbas Esvet, 2005, Farmaco (Lausanne), V60, P23, DOI 10.1016/j.farmac.2004.09.003
  • [8] β-aminoenones in the regioselective synthesis of 1,3,5-trialkylpyrazoles.: The influence of the substituents in the mechanism and the regioselectivity of the reaction
    Alberola, A
    González-Ortega, A
    Sádaba, ML
    Sañudo, MC
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (24): : 4061 - 4065
  • [9] Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistantStaphylococcus aureus
    Alnufaie, Rawan
    Alsup, Nickolas
    Raj, K. C. Hansa
    Newman, Matthew
    Whitt, Jedidiah
    Chambers, Steven Andrew
    Gilmore, David
    Alam, Mohammad A.
    [J]. JOURNAL OF ANTIBIOTICS, 2020, 73 (12) : 818 - 827
  • [10] Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureusAgents
    Alnufaie, Rawan
    Raj KC, Hansa
    Alsup, Nickolas
    Whitt, Jedidiah
    Andrew Chambers, Steven
    Gilmore, David
    Alam, Mohammad A.
    [J]. MOLECULES, 2020, 25 (12):
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