Amino acids and peptides. XXXVIII. Facile synthesis of laminin-related peptide-poly(ethylene glycol) hybrids by the solid phase method

被引：1

作者：

Maeda, M

Kamada, H

Hojo, K

Yamamoto, Y

Nakagawa, S

Smith, TJ

Mayumi, T

Kawasaki, K ^{[1
]}

机构：

[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

[2] Kobe Gakuin Univ, High Technol Res Ctr, Nishi Ku, Kobe, Hyogo 6512180, Japan

[3] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[4] Univ Pacific, Sch Pharm, San Francisco, CA 94118 USA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 04期

关键词：

poly(ethylene glycol); peptide-poly(ethylene glycol) hybrid; laminin; antimetastatic peptide; peptide synthesis;

D O I：

10.1248/cpb.49.488

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Poly(ethylene glycol) (PEG) has been studied as a drug-carrier for proteins, but not for small peptides, Laminin, a cell adhesive protein, has Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence and peptides containing this sequence inhibit experimental metastasis, We have studied PEC hybrids of YIGSR and other small laminin-related peptides, In a previous paper, we reported preparation of YIGSR-PEG hybrids by combination of the solid phase method and the solution method, but the synthetic procedure was problematic, Here we report a facile synthesis of PEG hybrids of YIGSR (PEG-YIGSR, YIGSR-PEG, PEG-YIGSR-PEG) by the solid phase method.

引用

页码：488 / 491

页数：4

共 15 条

[1] 9-FLUORENYLMETHOXYCARBONYL FUNCTION, A NEW BASE-SENSITIVE AMINO-PROTECTING GROUP [J].