Tensile properties of rat anterior cruciate ligament in collagen induced arthritis

被引：8
|
作者：
Nawata, K [1 ]
Enokida, M [1 ]
Yamasaki, D [1 ]
Minamizaki, T [1 ]
Hagino, H [1 ]
Morio, Y [1 ]
Teshima, R [1 ]
机构：
[1] Tottori Univ, Fac Med, Dept Orthopaed Surg, Tottori 6838504, Japan
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2001年 / 60卷 / 04期
关键词：
D O I：
10.1136/ard.60.4.395
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives-To investigate the effects of collagen induced arthritis (CIA) on the tensile properties of rat anterior cruciate Ligament (ACL). Methods-The tensile strength, bone mineral density (BMD), and histology of ACL units from rats with CIA were investigated. Results-The tensile strength of the ACL unit was significantly lower in the rats with CIA at 10 weeks after immunisation (ultimate failure load, 74.9% of the control; stiffness, 62.0% of the control). The major mode of failure was femoral avulsion, and the BMD was significantly lower in the rats with CIA. A histological examination of the ligament insertion in rats with CIA showed resorption of the cortical bone beneath the ACL insertion and an enlarged mineralised fibrocartilage zone. Conclusions-These findings indicate that the decrease in tensile strength of ACL units correlated with histological changes in the ligament-bone attachment, such as bone resorption beneath the ligament insertion site and an enlargement of the mineralised fibrocartilage zone.
引用
收藏
页码：395 / 398
页数：4
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