FGF23 or PTH: which comes first in CKD?

被引：50
作者：
Isakova, Tamara [1 ]
Wolf, Myles S. [1 ]
机构：
[1] Univ Miami, Div Nephrol & Hypertens, Dept Med, Miller Sch Med, Miami, FL 33136 USA
来源：
KIDNEY INTERNATIONAL | 2010年 / 78卷 / 10期
关键词：
FIBROBLAST GROWTH FACTOR-23; CHRONIC KIDNEY-DISEASE; FIBROBLAST-GROWTH-FACTOR-23;
D O I：
10.1038/ki.2010.281
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
In the past 40 years, disordered mineral metabolism has been among the most intensely studied areas of nephrology. A June 2010 PubMed search for 'secondary hyperparathyroidism and kidney disease' yielded 5866 references. Among these are papers documenting the development and application of numerous therapeutic agents-including calcitriol, vitamin D analogs, phosphate binders, and cinacalcet-that remain in widespread use in the day-to-day management of dialysis patients worldwide. However, almost 6000 papers later, fundamental pathophysiological concepts remain unclear, particularly regarding the early pathogenesis of disordered mineral metabolism.
引用
收藏
页码：947 / 949
页数：3
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