Synthetic (polymer) biology (membrane): functionalization of polymer scaffolds for membrane proteins

被引：15

作者：

Hu, Zhaolong ^{[1
]}

Ho, James C. S. ^{[1
]}

Nallani, Madhavan ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Dr, Singapore 637553, Singapore

[2] ACM Biolabs Pte Ltd, Innovat Ctr Block 2,18 Nanyang Dr, Singapore 637723, Singapore

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2017年 / 46卷

关键词：

DETERGENT-FREE ISOLATION; AMPHIPOLS; CHANNEL; RECONSTITUTION; EXPRESSION; SMALPS;

D O I：

10.1016/j.copbio.2016.10.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A plethora of polymer-based scaffolds have been designed to facilitate biochemical and biophysical investigation of membrane proteins, with a common goal to stabilize and present them in a functional format. In this review, an up-to-date account of such polymer-based supports and incorporation methodologies are presented. Furthermore, conceptual and imminent technological advances, with associated technical challenges are proposed.

引用

页码：51 / 56

页数：6

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