Acute kidney injury secondary to thrombotic microangiopathy associated with idiopathic hypereosinophilic syndrome: a case report and review of the literature

被引：2

作者：

Curras-Martin, Diana ^{[1
]}

Patel, Swapnil ^{[1
]}

Qaisar, Huzaif ^{[1
]}

Mehandru, Sushil K. ^{[1
]}

Masud, Avais ^{[1
]}

Hossain, Mohammad A. ^{[1
]}

Lamba, Gurpreet S. ^{[1
]}

Dounis, Harry ^{[1
]}

Levitt, Michael ^{[1
]}

Asif, Arif ^{[1
]}

机构：

[1] Jersey Shore Univ, Med Ctr, Hackensack Meridian Hlth, Dept Med,Internal Med Residency Program, Hackensack, NJ 07753 USA

来源：

JOURNAL OF MEDICAL CASE REPORTS | 2019年 / 13卷 / 01期

关键词：

Idiopathic hypereosinophilic syndrome; Eosinophilic cytotoxicity; Thrombotic microangiopathy; RENAL INVOLVEMENT; PATIENT;

D O I：

10.1186/s13256-019-2187-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Renal involvement in idiopathic hypereosinophilic syndrome is uncommon. The mechanism of kidney damage can be explained as occurring via two distinct pathways: (1) thromboembolic ischemic changes secondary to endocardial disruption mediated by eosinophilic cytotoxicity to the myocardium and (2) direct eosinophilic cytotoxic effect to the kidney. Case presentation We present a case of a 63-year-old Caucasian man who presented to our hospital with 2 weeks of progressively generalized weakness. He was diagnosed with idiopathic hypereosinophilic syndrome with multiorgan involvement and acute kidney injury with biopsy-proven thrombotic microangiopathy. Full remission was achieved after 8 weeks of corticosteroid therapy. Conclusion Further studies are needed to investigate if age and absence of frank thrombocytopenia can serve as a prognostic feature of idiopathic hypereosinophilic syndrome, as seen in this case.

引用

页数：6

共 25 条

[21] Renal involvement in idiopathic hypereosinophic syndrome
Shehwaro, Nathalie
Langlois, Anne Lyse
Gueutin, Victor
Izzedine, Hassane
[J]. CLINICAL KIDNEY JOURNAL, 2013, 6 (03): : 272 - 276
[22] Renal infarction in hypereosinophilic syndrome
Smith, A.
Fernando, S. L.
[J]. INTERNAL MEDICINE JOURNAL, 2012, 42 (10) : 1162 - 1163
[23] THE HYPEREOSINOPHILIC SYNDROME - CLINICAL-FEATURES, LABORATORY FINDINGS AND TREATMENT
SPRY, CJF
[J]. ALLERGY, 1982, 37 (08) : 539 - 551
[24] Thomas LL, 2000, CHEM IMMUNOL, V76, P99
[25] THE IDIOPATHIC HYPEREOSINOPHILIC SYNDROME
WELLER, PF
BUBLEY, GJ
[J]. BLOOD, 1994, 83 (10) : 2759 - 2779

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