Autoimmune haemolytic anaemia: a review and report of four cases

被引:0
作者
Renata, Nyilas [1 ]
Borbala, Szekely [1 ]
Laszlo, Varoczy [1 ]
Zsofia, Simon [1 ]
Anita, Arokszallasi [1 ]
Arpad, Illes [1 ]
Lajos, Gergely [1 ]
机构
[1] Debreceni Egyet, Klin Kozpont, Altalanos Orvostudomanyi Kar, Belgyogyaszati Intezet,Hematol Tanszek, Debrecen, Hungary
关键词
autoimmune haemolytic anaemia; lymphoma; steroid; rituximab; infection; bone marrow; LOW-DOSE RITUXIMAB; LAPAROSCOPIC SPLENECTOMY; HEMATOLOGIC DISEASES; AUTOANTIBODIES; COMPLICATIONS; COMBINATION; DIAGNOSIS; EFFICACY; OUTCOMES; THERAPY;
D O I
10.1556/OH.2015.30105
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Treatment of autoimmune haemolytic anaemia is still a challenge to clinicians. Even today it may be lethal. Half of the cases are secondary due to an underlying disease, and the others are primary or idiopathic cases. According to the specificity and type of autoantibodies there are warm and cold type forms of autoimmune haemolytic anaemia. The hallmark of the diagnosis is to detect the presence of haemolysis by clinical and laboratory signs and detect the underlying autoantibodies. Treatment of autoimmune haemolytic anaemia is still a challenge to clinicians. We still loose patients due to excessive haemolysis or severe infections caused by immunosuppression. First line treatment is corticosteroids. Other immunosuppressive agents like: cyclophosphamide, azathioprine, cyclosporine or the off label rituximab can be used in case of corticosteroid refractoriness. Splenectomy is a considerable option in selective cases. The authors discuss treatment options and highlight difficulties by presenting 4 cases.
引用
收藏
页码:449 / 456
页数:8
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