A pH-responsive emulsion stabilized by alginate-grafted anisotropic silica and its application in the controlled release of λ-cyhalothrin

被引：62
作者：
Chen, Kai [1 ]
Yu, Gaobo [1 ]
He, Furui [1 ]
Zhou, Qingfeng [1 ]
Xiao, Dunchao [1 ]
Li, Jiacheng [1 ]
Feng, Yuhong [1 ]
机构：
[1] Hainan Univ, Minist Educ, Sch Mat & Chem Engn, Key Lab Adv Mat Trop Isl Resources, Haikou 570228, Hainan, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2017年 / 176卷
基金：
中国国家自然科学基金;
关键词：
Alginate-grafted-silica; pH sensitivity; lambda-cyhalothrin; Sustained release; STARCH-BASED NANOPARTICLES; PICKERING EMULSION; DRUG-DELIVERY; MESOPOROUS SILICA; JANUS PARTICLES; RHEOLOGY; CHITOSAN; BEHAVIOR; SHAPE; NANO;
D O I：
10.1016/j.carbpol.2017.07.046
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Alginate (Alg) was grafted on the surface of anisotropic silica (SiO2-x) via the Ugi reaction (Alg-Si02-1, Alg-SiO2-2, and Alg-SiO2-4). Compared with pristine SiO2-x, modified SiO2-x is more sensitive to pH. Three stable liquid paraffin -in -water emulsions were prepared with Alg-SiO2-1, Alg-SiO2-2, and AlgSiO(2)-4. Alg-SiO2-2 exhibited satisfactory emulsification ability. The emulsions became more stable as emulsion pH varied from 2.0 to 6.2 because of polymer chain interactions that led to the formation of a three-dimensional network. When the emulsion pH varied from 6.2 to 8.0, the particle charge increased, in turn increasing interparticle the electrostatic interactions that increased emulsion stability. When the emulsion pH was 9.0, the subsequent decrease in particle charge, decreased the emulsion stability. The model drug X-cyhalothrin was embedded in the emulsions. A sustained -release assay demonstrated that increasing emulsion pH from 3.0 to 8.0 decreased cumulative drug release from the emulsion from 99.7% to 13.5%. This result indicated that the emulsion is a pH triggered drug delivery system. The sustained release curves of X-cyhalothrin are describable by the Weibull model. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：203 / 213
页数：11
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