Toward a versatile allylation reagent: Practical, enantioselective allylation of acylhydrazones using strained silacycles

被引：102

作者：

Berger, R ^{[1
]}

Rabbat, PMA ^{[1
]}

Leighton, JL ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 32期

关键词：

D O I：

10.1021/ja035001g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly practical method for the enantioselective allylation of acylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of acylhydrazones to give the hydrazide products with good enantioselectivity (83-89% ee, typically). It has been demonstrated that the products may be isolated without chromatography by recrystallization in ≥98% ee. Copyright © 2003 American Chemical Society.

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页码：9596 / 9597

页数：2

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