cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients

被引：38
|
作者：
Gatti, LL [1 ]
Souza, EKFE
Leite, KR
Bastos, ELD
Vicentini, LR
da Silva, LC
Smith, MDC
Payao, SLM
机构：
[1] Fac Med Marilia, FAMEMA, Homoctr, Disciplina Genet, BR-17519050 Marilia, SP, Brazil
[2] Fac Med Marilia, FAMEMA, Homoctr, Disciplina Biol Mol, BR-17519050 Marilia, SP, Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Genet, BR-04023900 Sao Paulo, Brazil
[4] Hosp Sirio Libanes, Lab Patol Mol, BR-01308050 Sao Paulo, Brazil
[5] Fac Med Marilia, FAMEMA, Disciplina Cirurg, BR-17519050 Marilia, SP, Brazil
[6] Fac Med Marilia, Serv Endoscopia, BR-17519050 Marilia, SP, Brazil
[7] Fac Med Marilia, FAMEMA, Disciplina Patol, BR-17519050 Marilia, SP, Brazil
[8] Univ Sao Paulo Bauru, BR-17011160 Sao Paulo, Brazil
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2005年 / 51卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
Helicobacter pylori; chronic gastritis; peptic ulcer disease; gastric malignancies; vacA; cagA; babA2;
D O I：
10.1016/j.diagmicrobio.2004.11.007
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with development of peptic ulcer disease and gastric malignancies. The vacuolating cytotoxin (vacA), cagA gene, and babA2 gene are important virulence factor involving gastric diseases. Eighty-nine Helicobacter pylori-positive gastric biopsies were analyzed by polymerase chain reaction and Southern blotting for H. pylori detection and genotyping with primer pairs from each virulence gene. Fifty-three strains (59%) were common vacA genotype s1/m1, and only 14 (16%) were s2/m2, 12% of strains was found to have multiple infection. The cagA presence was detected in 48% (43 strains) and babA2 gene was detected in 44% of our H. pylori strains. We observed high percentage of s1/m2 strains with chronic gastritis and peptic ulcer and a significant correlation between cagA presence with the s1 allele and babA2 gene with chronic gastritis. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：231 / 235
页数：5
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