Long-lasting effects of prenatal stress on HPA axis and inflammation: A systematic review and multilevel meta-analysis in rodent studies

被引：34

作者：

Creutzberg, Kerstin Camile ^{[1
]}

Sanson, Alice ^{[1
]}

Viola, Thiago Wendt ^{[2
]}

Marchisella, Francesca ^{[1
]}

Begni, Veronica ^{[1
]}

Grassi-Oliveira, Rodrigo ^{[2
]}

Riva, Marco Andrea ^{[1
,3
]}

机构：

[1] Univ Milan, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy

[2] Pontifical Univ Catolica Rio Grande Sul, Sch Med, Dev Cognit Neurosci Lab, Ave Ipiranga 6681,Bldg 12A, BR-90619900 Porto Alegre, RS, Brazil

[3] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Biol Psychiat Lab, Brescia, Italy

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2021年 / 127卷

关键词：

Prenatal stress; HPA; Cytokines; Meta-analysis; CORTICOTROPIN-RELEASING HORMONE; ANXIETY-LIKE BEHAVIOR; PITUITARY-ADRENAL AXIS; MESSENGER-RNA EXPRESSION; ANIMAL-MODELS; FEMALE RATS; ADULT MALE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; NEUROENDOCRINE RESPONSES; GESTATIONAL HYPOXIA;

D O I：

10.1016/j.neubiorev.2021.04.032

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Exposure to prenatal stress (PNS) can lead to long-lasting neurobiological and behavioral consequences for the offspring, which may enhance the susceptibility for mental disorders. The hypothalamus-pituitary-adrenal (HPA) axis and the immune system are two major factors involved in the stress response. Here, we performed a systematic review and meta-analysis of rodent studies that investigated the effects of PNS exposure on the HPA axis and inflammatory cytokines in adult offspring. Our analysis shows that animals exposed to PNS display a consistent increase in peripheral corticosterone (CORT) levels and central corticotrophin-releasing hormone (CRH), while decreased levels of its receptor 2 (CRHR2). Meta-regression revealed that sex and duration of PNS protocol are covariates that moderate these results. There was no significant effect of PNS in glucocorticoid receptor (GR), CRH receptor 1 (CRHR1), pro- and anti-inflammatory cytokines. Our findings suggest that PNS exposure elicits long-lasting effects on the HPA axis function, providing an important tool to investigate in preclinical settings key pathological aspects related to early-life stress exposure. Furthermore, researchers should be aware of the mixed outcomes of PNS on inflammatory markers in the adult brain.

引用

页码：270 / 283

页数：14

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