SYNTHESIS AND BIOEFFICACY TEST OF SOME NOVEL HALOGENATED-4-[(SUBSTITUTED-BENZOTHIAZOL-2-YL)-HYDRAZONO]-2-(SUBSTITUTED PHENYL)-5-METHYL-2, 4-DIHYDRO-PYRAZOL-3-ONE

被引：6
|
作者：
Sareen, V. [1 ]
Khatri, V. [1 ]
Sharma, K. [1 ]
Shinde, D. [1 ]
Sareen, S. [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
HETEROCYCLIC COMMUNICATIONS | 2010年 / 16卷 / 01期
关键词：
DERIVATIVES;
D O I：
10.1515/HC.2010.16.1.39
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Some new 4-[(substituted-benzothiazol-2-yl)-hydrazono]-2-(substituted phenyl) -5-methyl- 2, 4-dihydro-pyrazol-3-one (3) have been prepared by reacting substituted benzothiazol-2-yl amine with acetoacetic ester, 2-[substituted benzothiazol -2-yl)-hydrazono]-3-oxo-butyric acid ethyl ester (2) react with different hydrazines to give the title compounds. These compounds are evaluated for their antimicrobial activity. The structures of all these compounds have been confirmed by I.R., (1)HNMR,Mass spectra and elemental analysis data.
引用
收藏
页码：39 / 42
页数：4
相关论文
共 50 条
  • [41] Synthesis and antiulcer activity of 2-[5-substituted-1-H-benzo(d) imidazol-2-yl sulfinyl]methyl-3-substituted quinazoline-4-(3H) ones
    Patil, Avinash
    Ganguly, Swastika
    Surana, Sanjay
    JOURNAL OF CHEMICAL SCIENCES, 2010, 122 (03): : 443 - 450
  • [42] Synthesis, Antioxidant and Antidiabetic Activity of 1-[(5-Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole
    Kaushik, N.
    Kumar, N.
    Kumar, A.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 78 (03) : 351 - 359
  • [43] Synthesis, evaluation of antimicrobial activity, and molecular modeling of novel 2-((4-(2H-benzo[d] [1,2,3] triazol-2-yl)piperidin-1-yl)methyl)-5-substituted phenyl-1,3,4-oxadiazoles
    Vankadari, Srinivas Rao
    Mandala, Devender
    Pochampalli, Jalapathi
    Tigulla, Parthasarathy
    Valeru, Anil
    Thampu, Rajakomuraiah
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (12) : 5912 - 5919
  • [44] A facile synthesis of novel series (Z)-2-((4-oxo-5-(thiophen-2-ylmethylene)-4,5-dihydrothiazol-2-yl)amino) substituted acid
    Pansare, Dattatraya N.
    Shinde, Devanand B.
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2017, 21 (04) : 434 - 440
  • [45] Versatile Synthesis of 2-(Substituted phenyl)-6,7-dihydro-1H-indol-4(5H)-ones from Morita-Baylis-Hillman Acetates of 2-Oxo-2-(substituted phenyl)acetaldehyde
    Batchu, Harikrishna
    Batra, Sanjay
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (15) : 2935 - 2944
  • [46] Microwave-assisted synthesis of some new 2-(substituted phenyl)-3-(thiazol-2-yl)imidazo[4,5-b]indoles of biological interest
    Sharma, Gyanendra Kumar
    Singh, Gurvinder Pal
    Bhardwaj, Harsh
    Sharma, Umesh Kumar
    Singh, Manish Pal
    Bhardwaj, Himanshu
    Mishra, Akhileshar Prasad
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2024, 34 (03) : 373 - 378
  • [47] Pharmacological Study on Some New 3-[(1-Methylpyrrol-2-yl)methyl]-4-Substituted 4,5-Dihydro-1H-1,2,4-triazol-5-ones
    Pitucha, Monika
    Chodkowska, Anna
    Duda, Renata
    Jagiello-Wojtowicz, Ewa
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2009, 64 (9-10): : 615 - 618
  • [48] SYNTHESIS OF 2-(SUBSTITUTED PHENYL)-3-[5-(2-OXO-2H-CHROMEN-3-YL)-1,3,4-OXADIAZOL-2-YL]-1,3-THIAZOLIDIN-4-ONES WITH ANTIMICROBIAL ACTIVITY
    Bhat, Mashooq A.
    Al-Omar, Mohammed A.
    Siddiqui, Nadeem
    ACTA POLONIAE PHARMACEUTICA, 2011, 68 (02): : 295 - 299
  • [49] Facile synthesis of 4-((5-substituted-1H-indol-3-yl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ols by selective reduction
    Reddy, Gaddam Ganga
    Reddy, Chittireddy Venkata Ramana
    Dubey, Pramod Kumar
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2019, 58 (09): : 1042 - 1048
  • [50] Correlation between lipophilicity and antimicrobial activity of some 2-(4-substituted phenyl)-3(2H)-isothiazolones
    Rezaee, S.
    Khalaj, A.
    Adibpour, N.
    Saffary, M.
    DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 17 (04) : 256 - 263
12345