Electroreductive coupling of aliphatic amides.: A useful method for the synthesis of α-amino ketones

被引：12
|
作者：
Kashimura, S [1 ]
Ishifune, M [1 ]
Murai, Y [1 ]
Murase, H [1 ]
Shimomura, M [1 ]
Shono, T [1 ]
机构：
[1] Kinki Univ, Higashiosaka, Osaka 5778502, Japan
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 34期
关键词：
D O I：
10.1016/S0040-4039(98)01274-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Electroreduction of aliphatic amides (RCONMe2) with Mg electrode in the presence of chlorotrimethylsilane (TMSCl) has been found to give the coupling products [R(TMSO)C=C(NMe2)R] and hydrolysis of the products affords the corresponding alpha-amino ketones [RCOCH(NMe2)R] in excellent yields. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6199 / 6202
页数：4
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