Iron-Catalyzed Highly Enantioselective Hydrogenation of Alkenes

被引：41

作者：

Lu, Peng ^{[1
]}

Ren, Xiang ^{[1
]}

Xu, Haofeng ^{[1
]}

Lu, Dongpo ^{[1
]}

Sun, Yufeng ^{[1
]}

Lu, Zhan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2021年 / 143卷 / 32期

关键词：

ASYMMETRIC HYDROGENATION; HYDROBORATION; COMPLEXES; OLEFINS; HYDROSILYLATION; EFFICIENT; LIGANDS; ROUTE;

D O I：

10.1021/jacs.1c04773

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we reported for the first time an iron-catalyzed highly enantioselective hydrogenation of minimally functionalized 1,1-disubstituted alkenes to access chiral alkanes with full conversion and excellent ee. A novel chiral 8-oxazoline iminoquinoline ligand and its iron complex have been designed and synthesized. This protocol is operationally simple by using 1 atm of hydrogen gas and shows good functional group tolerance. A primary mechanism has been proposed by the deuterium-labeling experiments.

引用

页码：12433 / 12438

页数：6

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