CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1

被引：24

作者：

Chen, Jiaying ^{[1
]}

Zhang, Can ^{[1
]}

Mi, Yang ^{[1
]}

Chen, Fuxue ^{[1
]}

Du, Dongshu ^{[1
]}

机构：

[1] Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2017年 / 436卷 / 1-2期

关键词：

Glioma; CREB1; GLUT1; pCREB1; Glucose transport; EMBRYONIC STEM-CELLS; PROTEIN-KINASE-A; EXPRESSION; CANCER; BINDING; ACTIVATION; OVEREXPRESSION; PROLIFERATION; INHIBITION; MAPK;

D O I：

10.1007/s11010-017-3080-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glioma is stemmed from the glial cells in the brain, which is accounted for about 45% of all intracranial tumors. The characteristic of glioma is invasive growth, as well as there is no obvious boundary between normal brain tissue and glioma tissue, so it is difficult to resect completely with worst prognosis. The metabolism of glioma is following the Warburg effect. Previous researches have shown that GLUT1, as a glucose transporter carrier, affected the Warburg effect, but the molecular mechanism is not very clear. CREB1 (cAMP responsive element-binding protein1) is involved in various biological processes, and relevant studies confirmed that CREB1 protein regulated the expression of GLUT1, thus mediating glucose transport in cells. Our experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma.

引用

页码：79 / 86

页数：8

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