Asymmetric total synthesis of (-)-epibatidine

被引：36

作者：

Aoyagi, S ^{[1
]}

Tanaka, R ^{[1
]}

Naruse, M ^{[1
]}

Kibayashi, C ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 25期

关键词：

alkaloids; asymmetric synthesis; Diels-Alder reactions; nitroso compounds;

D O I：

10.1016/S0040-4039(98)00803-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective approach to (-)-epibatidine based on asymmetric hetero Diels-Alder cycloaddition with an N-acylnitroso dienophile bearing 8-(2-naphthyl)menthol as a chiral source, wherein pi-pi stacking interaction between the naphthyl and nitrosocarbonyl groups may contribute to facial control, is described. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4513 / 4516

页数：4

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