DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

被引：61

作者：

Zhou, Jing ^{[1
,2
,3
,4
,5
]}

Liu, Hao ^{[1
,2
]}

Zhang, Lian ^{[1
,2
]}

Liu, Xin ^{[1
,2
]}

Zhang, Chundong ^{[1
,2
]}

Wang, Yitao ^{[1
,2
]}

He, Qing ^{[1
,2
]}

Zhang, Ying ^{[1
,2
]}

Li, Yi ^{[1
,2
]}

Chen, Quanmei ^{[1
,2
]}

Zhang, Lu ^{[3
,4
,5
]}

Wang, Kui ^{[3
,4
,5
]}

Bu, Youquan ^{[1
,2
]}

Lei, Yunlong ^{[1
,2
]}

机构：

[1] Chongqing Med Univ, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China

[3] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China

[5] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China

来源：

CELL DEATH & DISEASE | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; BONE MORPHOGENETIC PROTEIN-4; GENE-LIKE; WNT/BETA-CATENIN; COLON-CANCER; SIGNALING PATHWAY; STEM-CELLS; EXPRESSION; REGULATOR; INVASION;

D O I：

10.1038/s41419-018-0883-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as a potential metastasis biomarker of CRC. In this study, we found that DJ-1 was upregulated in CRC. The levels of DJ-1 were closely correlated with the depths of invasion and predicted patient outcome. Enforced expression of DJ-1 could enhance CRC proliferation and metastasis in vitro and in vivo by stimulating Wnt-beta-catenin signaling. Specifically, DJ-1-induced beta-catenin nuclear translocation stimulated TCF transcription activity, which promoted BMP4 expression for CRC cell migration and invasion, and elevated CCND1 expression for CRC cell proliferation, respectively. Furthermore, DJ-1-induced Wnt signaling activation was dependent on PLAGL2 expression. In conclusion, our study demonstrates that DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis, suggesting novel therapeutic opportunities for postoperative adjuvant therapy in CRC patients.

引用

页数：12

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