DJ-1 promotes colorectal cancer progression through activating PLAGL2/Wnt/BMP4 axis

被引：61
作者：
Zhou, Jing [1 ,2 ,3 ,4 ,5 ]
Liu, Hao [1 ,2 ]
Zhang, Lian [1 ,2 ]
Liu, Xin [1 ,2 ]
Zhang, Chundong [1 ,2 ]
Wang, Yitao [1 ,2 ]
He, Qing [1 ,2 ]
Zhang, Ying [1 ,2 ]
Li, Yi [1 ,2 ]
Chen, Quanmei [1 ,2 ]
Zhang, Lu [3 ,4 ,5 ]
Wang, Kui [3 ,4 ,5 ]
Bu, Youquan [1 ,2 ]
Lei, Yunlong [1 ,2 ]
机构：
[1] Chongqing Med Univ, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China
[3] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China
[5] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China
来源：
CELL DEATH & DISEASE | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; BONE MORPHOGENETIC PROTEIN-4; GENE-LIKE; WNT/BETA-CATENIN; COLON-CANCER; SIGNALING PATHWAY; STEM-CELLS; EXPRESSION; REGULATOR; INVASION;
D O I：
10.1038/s41419-018-0883-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metastasis remains a big barrier for the clinical treatment of colorectal cancer (CRC). Our previous proteomics analysis identified DJ-1 as a potential metastasis biomarker of CRC. In this study, we found that DJ-1 was upregulated in CRC. The levels of DJ-1 were closely correlated with the depths of invasion and predicted patient outcome. Enforced expression of DJ-1 could enhance CRC proliferation and metastasis in vitro and in vivo by stimulating Wnt-beta-catenin signaling. Specifically, DJ-1-induced beta-catenin nuclear translocation stimulated TCF transcription activity, which promoted BMP4 expression for CRC cell migration and invasion, and elevated CCND1 expression for CRC cell proliferation, respectively. Furthermore, DJ-1-induced Wnt signaling activation was dependent on PLAGL2 expression. In conclusion, our study demonstrates that DJ-1 can promote CRC metastasis by activating PLAGL2-Wnt-BMP4 axis, suggesting novel therapeutic opportunities for postoperative adjuvant therapy in CRC patients.
引用
收藏
页数：12
相关论文
共 42 条
  • [1] Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling
    Ahmad, R.
    Kumar, B.
    Chen, Z.
    Chen, X.
    Mueller, D.
    Lele, S. M.
    Washington, M. K.
    Batra, S. K.
    Dhawan, P.
    Singh, A. B.
    [J]. ONCOGENE, 2017, 36 (47) : 6592 - 6604
  • [2] Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation
    Akiyoshi, T.
    Nakamura, M.
    Koga, K.
    Nakashima, H.
    Yao, T.
    Tsuneyoshi, M.
    Tanaka, M.
    Katano, M.
    [J]. GUT, 2006, 55 (07) : 991 - 999
  • [3] Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines
    Boon, EMJ
    Keller, JJ
    Wormhoudt, TAM
    Giardiello, FM
    Offerhaus, GJA
    van der Neut, R
    Pals, ST
    [J]. BRITISH JOURNAL OF CANCER, 2004, 90 (01) : 224 - 229
  • [4] Bowen KA, 2009, ANTICANCER RES, V29, P4439
  • [5] DJ-1 as a human oncogene and potential therapeutic target
    Cao, Ji
    Lou, Siyue
    Ying, Meidan
    Yang, Bo
    [J]. BIOCHEMICAL PHARMACOLOGY, 2015, 93 (03) : 241 - 250
  • [6] Hedgehog signaling pathway is inactive in colorectal cancer cell lines
    Chatel, Guillaume
    Ganeff, Corine
    Boussif, Naima
    Delacroix, Laurence
    Briquet, Alexandra
    Nolens, Gregory
    Winkler, Rosita
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (12) : 2622 - 2627
  • [7] PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial-Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
    Chen, Hai-Ning
    Yuan, Kefei
    Xie, Na
    Wang, Kui
    Huang, Zhao
    Chen, Yan
    Dou, Qianhui
    Wu, Min
    Nice, Edouard C.
    Zhou, Zong-Guang
    Huang, Canhua
    [J]. CANCER RESEARCH, 2016, 76 (05) : 1122 - 1134
  • [8] Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma
    Davidson, Ben
    Hadar, Rivka
    Schlossberg, Anat
    Sternlicht, Tamar
    Slipicevic, Ana
    Skrede, Martina
    Risberg, Bjoern
    Florenes, Vivi Ann
    Kopolovic, Juri
    Reich, Reuven
    [J]. HUMAN PATHOLOGY, 2008, 39 (01) : 87 - 95
  • [9] Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells
    Deng, Haiyun
    Makizumi, Ryouji
    Ravikumaya, T. S.
    Dong, Huali
    Yang, Wancai
    Yang, Weng-Lang
    [J]. EXPERIMENTAL CELL RESEARCH, 2007, 313 (05) : 1033 - 1044
  • [10] Overexpression of bone morphogenetic protein 4 enhances the invasiveness of Smad4-deficient human colorectal cancer cells
    Deng, Haiyun
    Ravikumar, T. S.
    Yang, Weng-Lang
    [J]. CANCER LETTERS, 2009, 281 (02) : 220 - 231
12345