Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy

被引：10
作者：
Lai, Xiangfeng [1 ,2 ]
Che, Chao [1 ,2 ,3 ]
机构：
[1] Peking Univ, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
[2] Peking Univ, Key Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
[3] BayRay Innovat Ctr, Shenzhen Bay Lab, Shenzhen 518055, Peoples R China
来源：
ACS OMEGA | 2020年 / 5卷 / 34期
基金：
中国国家自然科学基金;
关键词：
3-COMPONENT SYNTHESIS; CHEMISTRY; CHROMONE; SCAFFOLD;
D O I：
10.1021/acsomega.0c03589
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel three-component reaction of 2-oxo-2H-chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3-b]pyrrol-4(1H)-ones, which can also be transferred into diverse polycyclic fused scaffolds through further synthetic manipulations. The described method tolerates a broad substrate scope and proceeds in moderate to good yield via a sequential multicomponent reaction and intramolecular Michael cyclization.
引用
收藏
页码：21968 / 21977
页数：10
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