Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy

被引：10

作者：

Lai, Xiangfeng ^{[1
,2
]}

Che, Chao ^{[1
,2
,3
]}

机构：

[1] Peking Univ, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[2] Peking Univ, Key Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China

[3] BayRay Innovat Ctr, Shenzhen Bay Lab, Shenzhen 518055, Peoples R China

来源：

ACS OMEGA | 2020年 / 5卷 / 34期

基金：

中国国家自然科学基金;

关键词：

3-COMPONENT SYNTHESIS; CHEMISTRY; CHROMONE; SCAFFOLD;

D O I：

10.1021/acsomega.0c03589

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel three-component reaction of 2-oxo-2H-chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3-b]pyrrol-4(1H)-ones, which can also be transferred into diverse polycyclic fused scaffolds through further synthetic manipulations. The described method tolerates a broad substrate scope and proceeds in moderate to good yield via a sequential multicomponent reaction and intramolecular Michael cyclization.

引用

页码：21968 / 21977

页数：10

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