Fatigue in Patients with Lung Cancer Is Related with Accelerated Tryptophan Breakdown

被引：37

作者：

Kurz, Katharina ^{[1
,2
]}

Fiegl, Michael ^{[3
]}

Holzner, Bernhard ^{[4
]}

Giesinger, Johannes ^{[5
]}

Pircher, Marianna ^{[5
]}

Weiss, Guenter ^{[2
]}

Denz, Hubert A. ^{[5
]}

Fuchs, Dietmar ^{[1
]}

机构：

[1] Med Univ, Bioctr, Div Biol Chem, Innsbruck, Austria

[2] Med Univ, Div Clin Immunol & Infect Dis, Dept Internal Med, Innsbruck, Austria

[3] Med Univ, Div Hematol & Oncol, Dept Internal Med, Innsbruck, Austria

[4] Med Univ, Dept Psychiat & Psychotherapy, Innsbruck, Austria

[5] Hosp Natters, Div Oncol, Natters Innsbruck, Austria

来源：

PLOS ONE | 2012年 / 7卷 / 05期

关键词：

QUALITY-OF-LIFE; IMMUNE ACTIVATION; SERUM TRYPTOPHAN; INDOLEAMINE 2,3-DIOXYGENASE; HEMOGLOBIN LEVELS; INTERFERON-GAMMA; DEGRADATION; DEPRESSION; ANEMIA; METABOLISM;

D O I：

10.1371/journal.pone.0036956

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Patients with cancer often suffer from fatigue and decreased quality of life which might be related to the breakdown of essential amino acid tryptophan. Methods: In 50 patients with lung cancer we examined fatigue and the deterioration of quality of life in patients using the Functional Assessment of Cancer Therapy Anemia (FACT-An) and -Fatigue (FACT-F) subscales of FACT-General and the Mental adjustment to Cancer (MAC) questionnaires. Results were compared with tryptophan breakdown as well as serum concentrations of immune activation markers. Results: Scores of psychological tests correlated significantly with tryptophan breakdown and with circulatory markers of inflammation. However, immune activation and tryptophan breakdown were not related to MAC scores. Conclusions: Tryptophan breakdown relates with fatigue and impaired quality of life in patients with lung cancer, while declining tryptophan levels are not associated with patients'coping strategies.

引用

页数：9

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