Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction

被引：13

作者：

Cecconi, Alberto ^{[1
]}

Navarrete, Gonzalo ^{[1
]}

Garcia-Guimaraes, Marcos ^{[1
]}

Vera, Alberto ^{[1
]}

Blanco-Dominguez, Rafael ^{[2
]}

Sanz-Garcia, Ancor ^{[3
]}

Lozano-Prieto, Marta ^{[4
]}

Lopez-Melgar, Beatriz ^{[1
]}

Rivero, Fernando ^{[1
]}

Martin, Pilar ^{[2
,5
]}

Sanchez-Madrid, Francisco ^{[2
,4
,5
]}

de la Fuente, Hortensia ^{[4
,5
]}

Jesus Jimenez-Borreguero, Luis ^{[1
,5
]}

Alfonso, Fernando ^{[1
,5
]}

机构：

[1] Univ Autonoma Madrid, Hosp Univ Princesa IISP, Inst Invest Sanitaria, Dept Cardiol, C Diego de Leon 62, Madrid 28006, Spain

[2] Ctr Nacl Invest Cardiovasc CNIC, Vasc Pathophysiol Area, Madrid, Spain

[3] Hosp Univ Princesa, Inst Invest Sanitaria, Data Anal Unit, Madrid, Spain

[4] Univ Autonoma Madrid, Hosp Univ Princesa IISP, Inst Invest Sanitaria, Dept Immunol, C Diego de Leon 62, Madrid 28006, Spain

[5] Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

SHORT-TERM EXPOSURE; CARDIOVASCULAR-DISEASE; POLLUTION; RISK; INHALATION; SURVIVORS; PROTEIN; MIRNA;

D O I：

10.1038/s41598-022-09383-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Air pollutants increase the risk and mortality of myocardial infarction (MI). The aim of this study was to assess the inflammatory changes in circulating immune cells and microRNAs in MIs related to short-term exposure to air pollutants. We studied 192 patients with acute coronary syndromes and 57 controls with stable angina. For each patient, air pollution exposure in the 24-h before admission, was collected. All patients underwent systematic circulating inflammatory cell analyses. According to PM2.5 exposure, 31 patients were selected for microRNA analyses. STEMI patients exposed to PM2.5 showed a reduction of CD4(+) regulatory T cells. Furthermore, in STEMI patients the exposure to PM2.5 was associated with an increase of miR-146a-5p and miR-423-3p. In STEMI and NSTEMI patients PM2.5 exposure was associated with an increase of miR-let-7f-5p. STEMI related to PM2.5 short-term exposure is associated with changes involving regulatory T cells, miR-146a-5p and miR-423-3p.

引用

页数：12

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