Design, synthesis, in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial, antifungal and anti-tubercular agents

被引：62

作者：

Akhaja, Tarunkumar Nanjibhai ^{[1
]}

Raval, Jignesh Priyakant ^{[1
]}

机构：

[1] Ashok & Rita Patel Inst Integrated Study & Res Bi, Dept Pharmaceut Chem, New Vallabh Vidyanagar 388121, Gujarat, India

来源：

CHINESE CHEMICAL LETTERS | 2012年 / 23卷 / 04期

关键词：

Tetrahydropyrimidines; Isatin; 1,3-Dihydro-2H-indol-2-ones; Biginelli reaction; CaCl2; catalyst; In vitro antituberculer activity; Antibacterial and antifungal activity; DERIVATIVES;

D O I：

10.1016/j.cclet.2012.01.040

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 5-substitued-3-(5-(4-(furan-2-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-ylimino)indolin-2-one derivatives were synthesized, characterized and were screened for anti-bacterial, anti-fungal and antitubercular activity. (C) 2012 Jignesh Priyakant Raval. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights

引用

页码：446 / 449

页数：4

共 25 条

[1] 1,3-dihydro-2H-indol-2-ones derivatives: Design, Synthesis, in vitro antibacterial, antifungal and antitubercular study [J].