Design, synthesis, in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial, antifungal and anti-tubercular agents

被引：62
作者：
Akhaja, Tarunkumar Nanjibhai [1 ]
Raval, Jignesh Priyakant [1 ]
机构：
[1] Ashok & Rita Patel Inst Integrated Study & Res Bi, Dept Pharmaceut Chem, New Vallabh Vidyanagar 388121, Gujarat, India
来源：
CHINESE CHEMICAL LETTERS | 2012年 / 23卷 / 04期
关键词：
Tetrahydropyrimidines; Isatin; 1,3-Dihydro-2H-indol-2-ones; Biginelli reaction; CaCl2; catalyst; In vitro antituberculer activity; Antibacterial and antifungal activity; DERIVATIVES;
D O I：
10.1016/j.cclet.2012.01.040
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 5-substitued-3-(5-(4-(furan-2-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-ylimino)indolin-2-one derivatives were synthesized, characterized and were screened for anti-bacterial, anti-fungal and antitubercular activity. (C) 2012 Jignesh Priyakant Raval. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights
引用
收藏
页码：446 / 449
页数：4
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