Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery

被引：22
作者：
Shi, Jun [1 ]
Qi, Wenyan [1 ]
Li, Gefei [1 ]
Cao, Shaokui [1 ]
机构：
[1] Zhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450052, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Biomimetic; Nanocomposites; pH/temperature responsive; Self-assembly; Smart drug delivery; N-ISOPROPYLACRYLAMIDE; ALGINATE BEADS; NANOPARTICLES; FABRICATION; TEMPERATURE; CELLS; MINERALIZATION; COPOLYMERS; PARTICLES; MICROGELS;
D O I：
10.1016/j.msec.2012.04.008
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PM) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PM and Ca2+ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B-2 release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of Cap, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as "smart" nanoscale materials for sustained dual-responsive drug delivery. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：1299 / 1306
页数：8
相关论文
共 40 条
[1]   Switchable photoluminescence of CdTe nanocrystals by temperature-responsive microgels [J].
Agrawal, M. ;
Rubio-Retama, J. ;
Zafeiropoulos, N. E. ;
Gaponik, N. ;
Gupta, S. ;
Cimrova, V. ;
Lesnyak, V. ;
Lopez-Cabarcos, E. ;
Tzavalas, S. ;
Rojas-Reyna, R. ;
Eychmueller, A. ;
Stamm, M. .
LANGMUIR, 2008, 24 (17) :9820-9824
[2]   Temperature sensitive hybrid microgels loaded with ZnO nanoparticles [J].
Agrawal, Mukesh ;
Pich, Andrij ;
Gupta, Smrati ;
Zafeiropoulos, Nikolaos E. ;
Rubio-Retama, Jorge ;
Simon, Frank ;
Stamm, Manfred .
JOURNAL OF MATERIALS CHEMISTRY, 2008, 18 (22) :2581-2586
[3]   Recent developments in fabrication and applications of colloid based composite particles [J].
Agrawal, Mukesh ;
Gupta, Smrati ;
Stamm, Manfred .
JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (03) :615-627
[4]   Nanocomposite materials for optical applications [J].
Beecroft, LL ;
Ober, CK .
CHEMISTRY OF MATERIALS, 1997, 9 (06) :1302-1317
[5]   Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug [J].
Cao, Shao-Wen ;
Zhu, Ying-Jie ;
Wu, Jin ;
Wang, Ke-Wei ;
Tang, Qi-Li .
NANOSCALE RESEARCH LETTERS, 2010, 5 (04) :781-785
[6]   Application of calcium phosphate nanoparticles in biomedicine [J].
Epple, M. ;
Ganesan, K. ;
Heumann, R. ;
Klesing, J. ;
Kovtun, A. ;
Neumann, S. ;
Sokolova, V. .
JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (01) :18-23
[7]   Functional Hybrid Materials with Polymer Nanoparticles as Templates [J].
Ethirajan, Anitha ;
Landfester, Katharina .
CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (31) :9398-9412
[8]   Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells A Potential Mechanism in Atherosclerotic Plaque Destabilization [J].
Ewence, Alexandra E. ;
Bootman, Martin ;
Roderick, H. Llewelyn ;
Skepper, Jeremy N. ;
McCarthy, Geraldine ;
Epple, Matthias ;
Neumann, Markus ;
Shanahan, Catherine M. ;
Proudfoot, Diane .
CIRCULATION RESEARCH, 2008, 103 (05) :E28-E34
[9]   Stimuli-reponsive polymers and their bioconjugates [J].
Gil, ES ;
Hudson, SM .
PROGRESS IN POLYMER SCIENCE, 2004, 29 (12) :1173-1222
[10]   Poly(N-isopropyl acrylamide)-Gold Nanoassemblies on Macroscopic Surfaces: Fabrication, Characterization, and Application [J].
Gupta, Smrati ;
Agrawal, Mukesh ;
Uhlmann, Petra ;
Simon, Frank ;
Stamm, Manfred .
CHEMISTRY OF MATERIALS, 2010, 22 (02) :504-509
1234