NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

被引：61

作者：

Fionda, Cinzia ^{[1
]}

Soriani, Alessandra ^{[1
]}

Zingoni, Alessandra ^{[1
]}

Santoni, Angela ^{[1
]}

Cippitelli, Marco ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Pasteur Cenci Bolognetti Fdn Inst, Dept Mol Med, I-00161 Rome, Italy

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

GLYCOGEN-SYNTHASE KINASE-3; HISTONE DEACETYLASE INHIBITORS; NATURAL-KILLER-CELLS; UNFOLDED PROTEIN RESPONSE; TUMOR-SUPPRESSOR GENE; HLA CLASS-I; HSP90; INHIBITOR; DAMAGE RESPONSE; VALPROIC ACID; UP-REGULATION;

D O I：

10.1155/2015/178698

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A pivotal strategy to improve NK cell-mediated antitumor activity involves the upregulation of activating ligands on tumor cells. Enhancement of NK cell-mediated recognition of multiple myeloma cells was reported by us and others showing increased surface expression of NKG2D and DNAM-1 ligands on tumor cells following treatment with a number of chemotherapeutic agents, such as genotoxic drugs or inhibitors of proteasome, histone deacetylases, GSK3, andHSP-90. These compounds have the capability to affect tumor survival but also to activate specific transduction pathways associated with the upregulation of different NK cell activating ligands on the tumor cells. Here, we will summarize and discuss the molecular pathways whereby these drugs can regulate the expression of NK cell activating ligands in multiple myeloma cells.

引用

页数：9

共 98 条

[1] Use of bilevel positive airway pressure ventilatory support for pathological flail chest complicating multiple myeloma [J].

Abisheganaden, J ;

Chee, CBE ;

Wang, YT .

EUROPEAN RESPIRATORY JOURNAL, 1998, 12 (01) :238-239

[2] Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease [J].

Aoukaty, A ;

Tan, RS .

JOURNAL OF IMMUNOLOGY, 2005, 174 (08) :4551-4558

[3] Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D Ligands by the histone deacetylase inhibitor sodium valproate [J].

Armeanu, S ;

Bitzer, M ;

Lauer, UM ;

Venturelli, S ;

Pathil, A ;

Krusch, M ;

Kaiser, S ;

Jobst, K ;

Smirnow, I ;

Wagner, A ;

Steinle, A ;

Salih, HR .

CANCER RESEARCH, 2005, 65 (14) :6321-6329

[4] Heat Shock Protein 90 Is Critical for Regulation of Phenotype and Functional Activity of Human T Lymphocytes and NK Cells [J].

Bae, Jooeun ;

Munshi, Aditya ;

Li, Cheng ;

Samur, Mehmet ;

Prabhala, Rao ;

Mitsiades, Constantine ;

Anderson, Kenneth C. ;

Munshi, Nikhil C. .

JOURNAL OF IMMUNOLOGY, 2013, 190 (03) :1360-1371

[5] Novel Role for STAT3 in Transcriptional Regulation of NK Immune Cell Targeting Receptor MICA on Cancer Cells [J].

Bedel, Romain ;

Thiery-Vuillemin, Antoine ;

Grandclement, Camille ;

Balland, Jeremy ;

Remy-Martin, Jean-Paul ;

Kantelip, Bernadette ;

Pallandre, Jean-Rene ;

Pivot, Xavier ;

Ferrand, Christophe ;

Tiberghien, Pierre ;

Borg, Christophe .

CANCER RESEARCH, 2011, 71 (05) :1615-1626

[6] Differential regulation of STAT family members by glycogen synthase kinase-3 [J].

Beurel, Eleonore ;

Jope, Richard S. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (32) :21934-21944

[7] Building an antibody factory: a job for the unfolded protein response [J].

Brewer, JW ;

Hendershot, LM .

NATURE IMMUNOLOGY, 2005, 6 (01) :23-29

[8] HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells [J].

Carbone, E ;

Neri, P ;

Mesuraca, M ;

Fulciniti, MT ;

Otsuki, T ;

Pende, D ;

Groh, V ;

Spies, T ;

Pollio, G ;

Cosman, D ;

Catalano, L ;

Tassone, P ;

Rotoli, B ;

Venuta, S .

BLOOD, 2005, 105 (01) :251-258

[9] STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90α and β in multiple myeloma cells, which critically contribute to tumor-cell survival [J].

Chatterjee, Manik ;

Jain, Sarika ;

Stuehmer, Thorsten ;

Andrulis, Mindaugas ;

Ungethuem, Ute ;

Kuban, Ralf-Juergen ;

Lorentz, Heike ;

Bommert, Kurt ;

Topp, Max ;

Kraemer, Doris ;

Mueller-Hermelink, Hans Konrad ;

Einsele, Hermann ;

Greiner, Axel ;

Bargou, Ralf C. .

BLOOD, 2007, 109 (02) :720-728

[10] NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities [J].

Diermayr, Stefan ;

Himmelreich, Heike ;

Durovic, Bojana ;

Mathys-Schneeberger, Arina ;

Siegler, Uwe ;

Langenkamp, Ulrich ;

Hofsteenge, Jan ;

Gratwohl, Alois ;

Tichelli, Andr ;

Paluszewska, Monika ;

Wiktor-Jedrzejczak, Wieslaw ;

Kalberer, Christian P. ;

Wodnar-Filipowicz, Aleksandra .

BLOOD, 2008, 111 (03) :1428-1436

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