In Vitro Antioxidant Activities of New 4,5-Dihydro-1H-1,2,4-triazol-5-ones having Thiophene Ring with their Acidic Properties

被引：6
作者：
Yuksek, H. [1 ]
Islamoglu, F. [2 ]
Kol, O. Gursoy [1 ]
Bahceci, S. [3 ]
Bekar, M. [3 ]
Aksoy, M. [3 ]
机构：
[1] Kafkas Univ, Fac Sci & Arts, Dept Chem, TR-36100 Kars, Turkey
[2] Rize Univ, Fac Sci & Arts, Dept Chem, TR-53100 Rize, Turkey
[3] Karadeniz Tech Univ, Fatih Educ Fac, TR-61355 Trabzon, Turkey
来源：
E-JOURNAL OF CHEMISTRY | 2011年 / 8卷 / 04期
关键词：
4,5-Dihydro-1H-1,2,4-triazol-5-ones; Synthesis; Schiff bases; Acetylation; Acidity; Potentiometric titrations; NONAQUEOUS MEDIA; POTENTIOMETRIC TITRATIONS; ANTIMICROBIAL ACTIVITY; SUBSTITUTED ANILINES; ALIPHATIC-AMINES; BASICITY ORDER; DERIVATIVES; PYRIDINE;
D O I：
10.1155/2011/635459
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Seven new 3-alkyl(aryl)-4-(2-thienymethylenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with thiophene-2-carbaldehyde. In addition, N-acetyl derivatives of compounds 2d-2g were also prepared. The structures of eleven new compounds synthesized were determined by elemental analysis as well as IR, NMR and UV spectral data. In addition, compounds 2a-g and 3a, 3b, 3d-f were also screened for their antioxidant activities and 2a-g were potentiometrically titrated with tetrabutylammonium hydroxide (TBAH) in four nonaqueous solvents (isopropyl alcohol, t-butyl alcohol, acetonitrile and N,N-dimethyl formamide). Also half-neutralization potential values and the corresponding pKa values were determined in all cases.
引用
收藏
页码：1734 / 1746
页数：13
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