Synthesis of Novel Fused Heterocycles Based on 6-Amino-4-phenyl-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile

被引：11

作者：

Abdel-Ghany, H. ^{[1
]}

El-Sayed, A. M. ^{[1
]}

Amer, A. A. ^{[1
]}

Ahmed, A. M. ^{[1
]}

机构：

[1] Sohag Univ, Dept Chem, Fac Sci, Sohag, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 53卷 / 06期

关键词：

ANTIVIRAL ACTIVITY; CYCLASE STIMULATOR; DERIVATIVES; BAY-41-2272; DISCOVERY; DESIGN; POTENT; SERIES; SAR;

D O I：

10.1002/jhet.2522

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under phase transfer catalysis conditions, 6-amino-4-phenyl-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile (1) was allowed to react with halo compounds, acrylonitrile, chloroacetyl chloride, ethyl cyanoacetate, formamide, triethylorthoformate, or formic acid to give new derivatives of fused pyridines 2-22, respectively. Acetylation of compound 1 using acetic anhydride afforded product 23, which in turn underwent intramolecular cyclization in pyridine to give the corresponding pyrido[2,3-d]pyrimidine 24.

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收藏

页码：2013 / 2019

页数：7

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