Anthracyclines and ellipticines as DNA-damaging anticancer drugs: Recent advances

被引：134

作者：

Kizek, Rene ^{[1
]}

Adam, Vojtech ^{[1
]}

Hrabeta, Jan ^{[2
,3
]}

Eckschlager, Tomas ^{[2
,3
]}

Smutny, Svatopluk ^{[3
,4
]}

Burda, Jaroslav V. ^{[5
]}

Frei, Eva ^{[6
]}

Stiborova, Marie ^{[7
]}

机构：

[1] Mendel Univ Brno, Fac Agron, Dept Chem & Biochem, CZ-61300 Brno, Czech Republic

[2] Charles Univ Prague, Sch Med 2, Dept Paediat Haematol & Oncol, CZ-15006 Prague 5, Czech Republic

[3] Univ Hosp Motol, CZ-15006 Prague 5, Czech Republic

[4] Charles Univ Prague, Sch Med 2, Dept Surg 1, CZ-15006 Prague 5, Czech Republic

[5] Charles Univ Prague, Fac Math & Phys, Dept Chem Phys & Opt, CZ-12116 Prague 2, Czech Republic

[6] German Canc Res Ctr, Natl Ctr Tumor Dis, Div Prevent Oncol, D-69120 Heidelberg, Germany

[7] Charles Univ Prague, Fac Sci, Dept Biochem, CZ-12840 Prague 2, Czech Republic

来源：

PHARMACOLOGY & THERAPEUTICS | 2012年 / 133卷 / 01期

关键词：

Anthracyclines; Ellipticine; Adduct formation; Nanocarriers; CELL-CYCLE ARREST; PEROXIDASE-MEDIATED OXIDATION; METASTATIC BREAST-CANCER; ADDUCT FORMATION; PHASE-II; IN-VIVO; ANTITUMOR-ACTIVITY; CYTOCHROMES P450; DOXORUBICIN INTERACTIONS; TARGETED DELIVERY;

D O I：

10.1016/j.pharmthera.2011.07.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past forty years, anthracyclines and ellipticines have attracted attention as promising cytostatics. In this review, we focus on their mechanisms of cytoxicity, DNA-damaging effects and adverse side-effects. We also summarize ways to enhance the therapeutic effects of these drugs together with a decrease in their adverse effects. Current drug design strategies are focused on drug bioavailability and their tissue targeting, whereas drug delivery to specific intracellular compartments is rarely addressed. Therefore, therapies utilizing the antineoplastic activities of anthracyclines and ellipticines combined with novel strategies such as nanotechnologies for safer drug delivery, as well as strategies based on gene therapy, could significantly contribute to medical practice. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：26 / 39

页数：14

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