Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium

被引：43

作者：

d'Uscio, Livius V. ^{[1
]}

He, Tongrong

Katusic, Zvonimir S.

机构：

[1] Mayo Clin, Coll Med, Dept Anesthesiol & Mol Pharmacol, Rochester, MN 55902 USA

来源：

PHYSIOLOGY | 2017年 / 32卷 / 01期

关键词：

BLOOD-BRAIN-BARRIER; RECEPTOR-RELATED PROTEIN-1; A-BETA-PEPTIDES; ALZHEIMER-DISEASE PATIENTS; INTRACELLULAR DOMAIN AICD; INDUCED OXIDATIVE STRESS; NITRIC-OXIDE PRODUCTION; TRANSGENIC MOUSE MODEL; GLYCATION END-PRODUCTS; SMOOTH-MUSCLE-CELLS;

D O I：

10.1152/physiol.00021.2016

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium.

引用

页码：20 / 32

页数：13

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