Water, sanitation and hygiene related risk factors for soil-transmitted helminth and Giardia duodenalis infections in rural communities in Timor-Leste

被引:26
作者
Campbell, Suzy J. [1 ,8 ]
Nery, Susana V. [1 ]
D'Este, Catherine A. [1 ]
Gray, Darren J. [1 ,2 ,3 ]
McCarthy, James S. [3 ,4 ]
Traub, Rebecca J. [5 ]
Andrews, Ross M. [6 ]
Llewellyn, Stacey [4 ]
Vallely, Andrew J. [7 ]
Williams, Gail M. [3 ]
Amaral, Salvador [1 ]
Clements, Archie C. A. [1 ]
机构
[1] Australian Natl Univ, Coll Med Biol & Environm, Res Sch Populat Hlth, 62 Mills Rd, Acton, ACT 2601, Australia
[2] QIMR Berghofer Med Res Inst, Mol Parasitol Lab, 300 Herston Rd, Brisbane, Qld 4006, Australia
[3] Univ Queensland, Sch Publ Hlth, Herston Rd, Brisbane, Qld 4006, Australia
[4] QIMR Berghofer Med Res Inst, Clin Trop Med Lab, 300 Herston Rd, Brisbane, Qld 4006, Australia
[5] Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia
[6] Charles Darwin Univ, Menzies Sch Hlth Res, Ellengowan Dr, Casuarina, NT 0810, Australia
[7] Univ New South Wales, Kirby Inst, Wallace Wurth Bldg,High St, Kensington, NSW 2052, Australia
[8] Univ Liverpool Liverpool Sch Trop Med, Pembroke Pl, Liverpool L3 5QA, Merseyside, England
基金
澳大利亚国家健康与医学研究理事会;
关键词
Soil transmitted; Helminth; Hookworm; Necator americanus; Ascaris lumbricoides; Giardia; Prevalence; Risk factor; HOOKWORM INFECTION; TEMPLE COMMUNITIES; NECATOR INFECTION; HAINAN PROVINCE; PREVALENCE; HUMANS; DOGS; EPIDEMIOLOGY; TRANSMISSION; INTENSITY;
D O I
10.1016/j.ijpara.2016.07.005
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
There is little evidence on prevalence or risk factors for soil transmitted helminth infections in Timor-Leste. This study describes the epidemiology, water, sanitation and hygiene, and socioeconomic risk factors of STH and intestinal protozoa amongst communities in Manufahi District, Timor-Leste. As part of a cluster randomised controlled trial, a baseline cross-sectional survey was conducted across 18 villages, with data from six additional villages. Stool samples were assessed for soil transmitted helminth and protozoal infections using quantitative PCR (qPCR) and questionnaires administered to collect water, sanitation and hygiene and socioeconomic data. Risk factors for infection were assessed using multivariable mixed-effects logistic regression, stratified by age group (preschool, school-aged and adult). Overall, soil transmitted helminth prevalence was 69% (95% Confidence Interval 67-71%), with Necator americanus being most common (60%; 95% Confidence Interval 58-62%) followed by Ascaris spp. (24%; 95% Confidence Interval 23-26%). Ascaris-N. americanus co-infection was common (17%; 95% Confidence Interval 15%-18%). Giardia duodenalis was the main protozoan identified (13%; 95% Confidence Interval 11-14%). Baseline water, sanitation and hygiene infrastructure and behaviours were poor. Although risk factors varied by age of participants and parasite species, risk factors for N. americanus infection included, generally, age in years, male sex, and socioeconomic quintile. Risk factors for Ascaris included age in years for children, and piped water to the yard for adults. In this first known assessment of community-based prevalence and associated risk factors in Timor-Leste, soil transmitted helminth infections were highly prevalent, indicating a need for soil transmitted helminth control. Few associations with water, sanitation and hygiene were evident, despite water, sanitation and hygiene being generally poor. In our water, sanitation and hygiene we will investigate implications of improving WASH on soil transmitted helminth infection in impoverished communities. (C) 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:771 / 779
页数:9
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