Multi-Omic Approaches in Colorectal Cancer beyond Genomic Data

被引：11

作者：

Sardo, Emilia ^{[1
]}

Napolitano, Stefania ^{[1
]}

Della Corte, Carminia Maria ^{[1
]}

Ciardiello, Davide ^{[2
]}

Raucci, Antonio ^{[3
]}

Arrichiello, Gianluca ^{[1
]}

Troiani, Teresa ^{[1
]}

Ciardiello, Fortunato ^{[1
]}

Martinelli, Erika ^{[1
]}

Martini, Giulia ^{[1
]}

机构：

[1] Univ Campania L Vanvitelli, Oncol Med, Dipartimento Med Precis, I-80131 Naples, Italy

[2] Fdn IRCCS Casa Sollievo Sofferenza, Oncol Med, I-71013 San Giovanni Rotondo, Italy

[3] AORN Antonio Cardarelli, UOC Radiol Gen & Pronto Soccorso, I-80131 Naples, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 02期

关键词：

omics; colorectal cancer; biomarkers; multiparametric approach; CONSENSUS MOLECULAR SUBTYPES; MICROSATELLITE INSTABILITY; IMMUNE LANDSCAPE; F-18-FDG PET/CT; GUT MICROBIOTA; KRAS MUTATION; COLON; TUMORS; CELLS; BIOMARKERS;

D O I：

10.3390/jpm12020128

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Colorectal cancer (CRC) is one of the most frequent tumours and one of the major causes of morbidity and mortality globally. Its incidence has increased in recent years and could be linked to unhealthy dietary habits combined with environmental and hereditary factors, which can lead to genetic and epigenetic changes and induce tumour development. The model of CRC progression has always been based on a genomic, parametric, static and complex approach involving oncogenes and tumour suppressor genes. Recent advances in omics sciences have sought a paradigm shift to a multiparametric, immunological-stromal, and dynamic approach for a better understanding of carcinogenesis and tumour heterogeneity. In the present paper, we review the most important preclinical and clinical data and present recent discoveries in the field of transcriptomics, proteomics, metagenomics and radiomics in CRC disease.

引用

页数：14

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