ICAM-5-A novel two-facetted adhesion molecule in the mammalian brain

被引：55

作者：

Gahmberg, Carl G. ^{[1
]}

Tian, Li ^{[1
]}

Ning, Lin ^{[1
]}

Nyman-Huttunen, Henrietta ^{[1
]}

机构：

[1] Univ Helsinki, Fac Biosci, Div Biochem, FIN-00014 Helsinki, Finland

来源：

IMMUNOLOGY LETTERS | 2008年 / 117卷 / 02期

基金：

芬兰科学院;

关键词：

ICAM-5; telencephalin; LFA-1; glutamate receptors; cytoskeleton integrins;

D O I：

10.1016/j.imlet.2008.02.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell adhesion is of utmost importance for normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin) is a member of the ICAM-family of adhesion proteins. These proteins bind to leukocyte beta(2)-integrins (CD11/CD18), but ICAM-5 is exceptional in several ways. It is solely expressed in the mammalian forebrain, appears at the time of birth, and is located in the soma and dendrites of neurons. It is structurally more complex than the others, and also shows homophilic adhesion. Recent studies show that it is important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：131 / 135

页数：5

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