D-Serine as a putative glial neurotransmitter

被引：55

作者：

Mustafa, Asif K. ^{[2
]}

Kim, Paul M. ^{[3
]}

Snyder, Solomon H. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, Baltimore, MD 21205 USA

来源：

NEURON GLIA BIOLOGY | 2004年 / 1卷

关键词：

alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor; D-serine; N-methyl-D-aspartate receptor; serine racemase;

D O I：

10.1017/S1740925X05000141

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Abundant recent evidence favors a neurotransmitter/neuromodulator role for D-serine. D-serine is synthesized from L-serine by serine racemase in astrocytic glia that ensheath synapses, especially in regions of the brain that are enriched in NMDA-glutamate receptors. D-serine is more potent than glycine at activating the 'glycine' site of these receptors. Moreover, selective degradation of D-serine but not glycine by D-amino acid oxidase markedly reduces NMDA neurotransmission. D-serine appears to be released physiologically in response to activation by glutamate of AMPA-glutamate receptors oil D-serine-containing glia. This causes glutamate-receptor-interacting protein, which binds serine racemase, to stimulate enzyme activity and D-serine release. Thus, glutamate triggers the release of D-serine so that the two amino acids call act together on postsynaptic NMDA receptors. D-serine also plays a role in neural development, being released from Bergmann glia to chemokinetically enhance the migration of granule cell cerebellar neurons from the external to the internal granular layer.

引用

页码：275 / 281

页数：7

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